A comparison study between electrospun polycaprolactone and piezoelectric poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds for bone tissue engineering

A comparison study between electrospun polycaprolactone and piezoelectric poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds for bone tissue engineering

Bibliographic Details
Parent link:Colloids and Surfaces B: Biointerfaces
Vol. 157.— 2017.— [P. 48-59]
Corporate Authors: Национальный исследовательский Томский политехнический университет (ТПУ) Управление проректора по научной работе и инновациям (НРиИ) Центр RASA в Томске Лаборатория новых лекарственных форм (Лаб. НЛФ), Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Кафедра экспериментальной физики (ЭФ)
Other Authors: Gorodzha S. N. Svetlana Nikolaevna, Muslimov A. R. Albert Radikovich, Syromotina D. S. Dina Sergeevna, Timin A. S. Aleksandr Sergeevich, Tsvetkov N. Yu. Nikolay Yurjevich, Lepik K. V. Kirill Viktorovich, Petrova A. V. Aleksandra Vladilenovna, Surmeneva M. A. Maria Alexandrovna, Gorin D. A. Dmitry Aleksandrovich, Sukhorukov G. B. Gleb Borisovich, Surmenev R. A. Roman Anatolievich
Summary:Title screen
In this study, bone scaffolds composed of polycaprolactone (PCL), piezoelectric poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and a combination of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and silicate containing hydroxyapatite (PHBV-SiHA) were successfully fabricated by a conventional electrospinning process. The morphological, chemical, wetting and biological properties of the scaffolds were examined. All fabricated scaffolds are composed of randomly oriented fibres with diameters from 800 nm to 12 µm. Fibre size increased with the addition of SiHA to PHBV scaffolds. Moreover, fibre surface roughness in the case of hybrid scaffolds was also increased. XRD, FTIR and Raman spectroscopy were used to analyse the chemical composition of the scaffolds, and contact angle measurements were performed to reveal the wetting behaviour of the synthesized materials. To determine the influence of the piezoelectric nature of PHBV in combination with SiHA nanoparticles on cell attachment and proliferation, PCL (non-piezoelectric), pure PHBV, and PHBV-SiHA scaffolds were seeded with human mesenchymal stem cells (hMSCs). In vitro study on hMSC adhesion, viability, spreading and osteogenic differentiation showed that the PHBV-SiHA scaffolds had the largest adhesion and differentiation abilities compared with other scaffolds. Moreover, the piezoelectric PHBV scaffolds have demonstrated better calcium deposition potential compared with non-piezoelectric PCL. The results of the study revealed pronounced advantages of hybrid PHBV-SiHA scaffolds to be used in bone tissue engineering.
Режим доступа: по договору с организацией-держателем ресурса
Published: 2017
Subjects:
электронный ресурс
труды учёных ТПУ
polymer scaffolds
nanoparticles
cell adhesion
mineralization
electrospinning
наночастицы
клеточная адгезия
минерализация
электроспиннинг
полимеры
Online Access:https://doi.org/10.1016/j.colsurfb.2017.09.004
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=656814

Internet

https://doi.org/10.1016/j.colsurfb.2017.09.004

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