Flavoprotein miniSOG Cytotoxisity Can Be Induced By Bioluminescence Resonance Energy Transfer; Acta Naturae; Vol. 8, №4 (31)

Flavoprotein miniSOG Cytotoxisity Can Be Induced By Bioluminescence Resonance Energy Transfer; Acta Naturae; Vol. 8, №4 (31)

التفاصيل البيبلوغرافية
Parent link:Acta Naturae
Vol. 8, №4 (31).— 2016.— [P. 118-123]
مؤلف مشترك: Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Лаборатория радиационного контроля № 31 (Лаборатория РК № 31)
مؤلفون آخرون: Shramova E. I. Elena Ivanovna, Proshkina G. M. Galina Mikhaylovna, Chumakov S. P. Stepan Petrovich, Khodarovich Y. M. Yury Mikhaylovich, Deev S. M. Sergey Mikhaylovich
الملخص:Title screen
In this study, we investigated the possibility of phototoxic flavoprotein miniSOG (photosensitizer) excitation in cancer cells by bioluminescence occurring when luciferase NanoLuc oxidizes its substrate, furimazine. We have shown that the phototoxic flavoprotein miniSOG expressed in eukaryotic cells in fusion with NanoLuc luciferase is activated in the presence of its substrate, furimazine. Upon such condition, miniSOG possesses photoinduced cytotoxicity and causes a 48% cell death level in a stably transfected cell line.
اللغة:الإنجليزية
منشور في: 2016
الموضوعات:
электронный ресурс
труды учёных ТПУ
luminescence
биолюминесценция
фотодинамическая терапия
окисление
субстраты
الوصول للمادة أونلاين:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199213/
التنسيق: الكتروني فصل الكتاب
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=655446

الانترنت

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199213/

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