Flavoprotein miniSOG Cytotoxisity Can Be Induced By Bioluminescence Resonance Energy Transfer; Acta Naturae; Vol. 8, №4 (31)

Flavoprotein miniSOG Cytotoxisity Can Be Induced By Bioluminescence Resonance Energy Transfer

Bibliographic Details
Parent link:	Acta Naturae Vol. 8, №4 (31).— 2016.— [P. 118-123]
Corporate Author:	Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Лаборатория радиационного контроля № 31 (Лаборатория РК № 31)
Other Authors:	Shramova E. I. Elena Ivanovna, Proshkina G. M. Galina Mikhaylovna, Chumakov S. P. Stepan Petrovich, Khodarovich Y. M. Yury Mikhaylovich, Deev S. M. Sergey Mikhaylovich
Summary:	Title screen In this study, we investigated the possibility of phototoxic flavoprotein miniSOG (photosensitizer) excitation in cancer cells by bioluminescence occurring when luciferase NanoLuc oxidizes its substrate, furimazine. We have shown that the phototoxic flavoprotein miniSOG expressed in eukaryotic cells in fusion with NanoLuc luciferase is activated in the presence of its substrate, furimazine. Upon such condition, miniSOG possesses photoinduced cytotoxicity and causes a 48% cell death level in a stably transfected cell line.
Language:	English
Published:	2016
Subjects:	электронный ресурс труды учёных ТПУ luminescence биолюминесценция фотодинамическая терапия окисление субстраты
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199213/
Format:	Electronic Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=655446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199213/