Flavoprotein miniSOG Cytotoxisity Can Be Induced By Bioluminescence Resonance Energy Transfer; Acta Naturae; Vol. 8, №4 (31)
| Parent link: | Acta Naturae Vol. 8, №4 (31).— 2016.— [P. 118-123] |
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| Institution som forfatter: | |
| Andre forfattere: | , , , , |
| Summary: | Title screen In this study, we investigated the possibility of phototoxic flavoprotein miniSOG (photosensitizer) excitation in cancer cells by bioluminescence occurring when luciferase NanoLuc oxidizes its substrate, furimazine. We have shown that the phototoxic flavoprotein miniSOG expressed in eukaryotic cells in fusion with NanoLuc luciferase is activated in the presence of its substrate, furimazine. Upon such condition, miniSOG possesses photoinduced cytotoxicity and causes a 48% cell death level in a stably transfected cell line. |
| Sprog: | engelsk |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199213/ |
| Format: | Electronisk Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=655446 |
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| 200 | 1 | |a Flavoprotein miniSOG Cytotoxisity Can Be Induced By Bioluminescence Resonance Energy Transfer |f E. I. Shramova [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: p. 123 (29 tit.)] | ||
| 330 | |a In this study, we investigated the possibility of phototoxic flavoprotein miniSOG (photosensitizer) excitation in cancer cells by bioluminescence occurring when luciferase NanoLuc oxidizes its substrate, furimazine. We have shown that the phototoxic flavoprotein miniSOG expressed in eukaryotic cells in fusion with NanoLuc luciferase is activated in the presence of its substrate, furimazine. Upon such condition, miniSOG possesses photoinduced cytotoxicity and causes a 48% cell death level in a stably transfected cell line. | ||
| 461 | |t Acta Naturae | ||
| 463 | |t Vol. 8, №4 (31) |v [P. 118-123] |d 2016 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a luminescence | |
| 610 | 1 | |a биолюминесценция | |
| 610 | 1 | |a фотодинамическая терапия | |
| 610 | 1 | |a окисление | |
| 610 | 1 | |a субстраты | |
| 701 | 1 | |a Shramova |b E. I. |g Elena Ivanovna | |
| 701 | 1 | |a Proshkina |b G. M. |g Galina Mikhaylovna | |
| 701 | 1 | |a Chumakov |b S. P. |g Stepan Petrovich | |
| 701 | 1 | |a Khodarovich |b Y. M. |g Yury Mikhaylovich | |
| 701 | 1 | |a Deev |b S. M. |c biologist |c Leading Researcher, Tomsk Polytechnic University, Doctor of Biological Sciences |f 1951- |g Sergey Mikhaylovich |3 (RuTPU)RU\TPU\pers\39299 |9 20959 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет (ТПУ) |b Физико-технический институт (ФТИ) |b Лаборатория радиационного контроля № 31 (Лаборатория РК № 31) |3 (RuTPU)RU\TPU\col\19161 |
| 801 | 2 | |a RU |b 63413507 |c 20170906 |g RCR | |
| 856 | 4 | |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199213/ | |
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