Flavoprotein miniSOG Cytotoxisity Can Be Induced By Bioluminescence Resonance Energy Transfer; Acta Naturae; Vol. 8, №4 (31)

Flavoprotein miniSOG Cytotoxisity Can Be Induced By Bioluminescence Resonance Energy Transfer

ग्रंथसूची विवरण
Parent link:Acta Naturae
Vol. 8, №4 (31).— 2016.— [P. 118-123]
निगमित लेखक: Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Лаборатория радиационного контроля № 31 (Лаборатория РК № 31)
अन्य लेखक: Shramova E. I. Elena Ivanovna, Proshkina G. M. Galina Mikhaylovna, Chumakov S. P. Stepan Petrovich, Khodarovich Y. M. Yury Mikhaylovich, Deev S. M. Sergey Mikhaylovich
सारांश:Title screen
In this study, we investigated the possibility of phototoxic flavoprotein miniSOG (photosensitizer) excitation in cancer cells by bioluminescence occurring when luciferase NanoLuc oxidizes its substrate, furimazine. We have shown that the phototoxic flavoprotein miniSOG expressed in eukaryotic cells in fusion with NanoLuc luciferase is activated in the presence of its substrate, furimazine. Upon such condition, miniSOG possesses photoinduced cytotoxicity and causes a 48% cell death level in a stably transfected cell line.
भाषा:अंग्रेज़ी
प्रकाशित: 2016
विषय:
электронный ресурс
труды учёных ТПУ
luminescence
биолюминесценция
фотодинамическая терапия
окисление
субстраты
ऑनलाइन पहुंच:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199213/
स्वरूप: इलेक्ट्रोनिक पुस्तक अध्याय
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=655446
विवरण
सारांश:Title screen
In this study, we investigated the possibility of phototoxic flavoprotein miniSOG (photosensitizer) excitation in cancer cells by bioluminescence occurring when luciferase NanoLuc oxidizes its substrate, furimazine. We have shown that the phototoxic flavoprotein miniSOG expressed in eukaryotic cells in fusion with NanoLuc luciferase is activated in the presence of its substrate, furimazine. Upon such condition, miniSOG possesses photoinduced cytotoxicity and causes a 48% cell death level in a stably transfected cell line.

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