A new approach for the immobilization of poly(acrylic) acid as a chemically reactive cross-linker on the surface of poly(lactic) acid-based biomaterials; Materials Science and Engineering: C; Vol. 71
| Parent link: | Materials Science and Engineering: C.— , 1993- Vol. 71.— 2017.— [P. 862–869] |
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| Körperschaften: | , |
| Weitere Verfasser: | , , , , , |
| Zusammenfassung: | Title screen A new approach for the immobilization of poly(acrylic) acid (PAA) as a chemically reactive cross-linker on thesurface of poly(lactic) acid-based (PLA) biomaterials is described. The proposed technique includes noncovalentattachment of a PAA layer to the surface of PLA-based biomaterial via biomaterial surface treatmentwith solvent/non-solvent mixture followed by the entrapment of PAA from its solution. Surface morphologyand wettability of the obtained PLA-PAA composite materials were investigated by AFM and the sitting dropmethod respectively. The amount of the carboxyl groups on the composites surface was determined by usingthe fluorescent compounds (2-(5-aminobenzo[d]oxazol-2-yl)phenol (ABO) and its acyl derivative N-(2-(2-hydroxyphenyl)benzo[d]oxazol-5-yl)acetamide (AcABO)). It was shown that it is possible to obtain PLA-PAAcomposites with various surface relief and tunable wettability (57C, 62C and 66C). The capacity of the createdPAA layer could be varied from 1.5 nmol/cm2 to 0.1 µmol/cm2 depending on the modification conditions. Additionally,using bovine serum albumin (BSA) it was demonstrated that such composites could be modified withproteins with high binding density (around 0.18 nmol/cm2). Obtained fluoro-labeled PLA-PAA materials, aswell as PLA-PAA composites themselves, are valuable since they can be used for biodegradable polymer implantstracking in living systems and as drug delivery systems. Режим доступа: по договору с организацией-держателем ресурса |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online-Zugang: | http://dx.doi.org/10.1016/j.msec.2016.10.078 |
| Format: | MixedMaterials Elektronisch Buchkapitel |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=653223 |
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| 200 | 1 | |a A new approach for the immobilization of poly(acrylic) acid as a chemically reactive cross-linker on the surface of poly(lactic) acid-based biomaterials |f K. S. Stankevich [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: p. 869 (37 tit.)] | ||
| 330 | |a A new approach for the immobilization of poly(acrylic) acid (PAA) as a chemically reactive cross-linker on thesurface of poly(lactic) acid-based (PLA) biomaterials is described. The proposed technique includes noncovalentattachment of a PAA layer to the surface of PLA-based biomaterial via biomaterial surface treatmentwith solvent/non-solvent mixture followed by the entrapment of PAA from its solution. Surface morphologyand wettability of the obtained PLA-PAA composite materials were investigated by AFM and the sitting dropmethod respectively. The amount of the carboxyl groups on the composites surface was determined by usingthe fluorescent compounds (2-(5-aminobenzo[d]oxazol-2-yl)phenol (ABO) and its acyl derivative N-(2-(2-hydroxyphenyl)benzo[d]oxazol-5-yl)acetamide (AcABO)). It was shown that it is possible to obtain PLA-PAAcomposites with various surface relief and tunable wettability (57C, 62C and 66C). The capacity of the createdPAA layer could be varied from 1.5 nmol/cm2 to 0.1 µmol/cm2 depending on the modification conditions. Additionally,using bovine serum albumin (BSA) it was demonstrated that such composites could be modified withproteins with high binding density (around 0.18 nmol/cm2). Obtained fluoro-labeled PLA-PAA materials, aswell as PLA-PAA composites themselves, are valuable since they can be used for biodegradable polymer implantstracking in living systems and as drug delivery systems. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Materials Science and Engineering: C |d 1993- | ||
| 463 | |t Vol. 71 |v [P. 862–869] |d 2017 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a poly(lactic) acid | |
| 610 | 1 | |a poly(acrylic) acid | |
| 610 | 1 | |a surface modification | |
| 610 | 1 | |a entrapment | |
| 610 | 1 | |a composite materials | |
| 610 | 1 | |a fluorescent compounds | |
| 610 | 1 | |a bovine serum albumin | |
| 610 | 1 | |a полимолочная кислота | |
| 610 | 1 | |a полиакриловая кислота | |
| 610 | 1 | |a поверхности | |
| 610 | 1 | |a модификации | |
| 610 | 1 | |a защемления | |
| 610 | 1 | |a композиционные материалы | |
| 610 | 1 | |a флуоресцентные соединения | |
| 701 | 1 | |a Stankevich |b K. S. |c Physicist |c Engineer Tomsk Polytechnic University |f 1992- |g Ksenia Sergeevna |3 (RuTPU)RU\TPU\pers\37546 | |
| 701 | 1 | |a Danilenko |b N. V. |c chemical engineer |c Research Engineer, Tomsk Polytechnic University |f 1992- |g Nadezhda Viktorovna |3 (RuTPU)RU\TPU\pers\37547 |9 20416 | |
| 701 | 1 | |a Gadirov |b R. M. |g Ruslan Mukhamedzhanovich | |
| 701 | 1 | |a Goreninsky (Goreninskii) |b S. I. |c chemist |c engineer of Tomsk Polytechnic University |f 1993- |g Semen Igorevich |3 (RuTPU)RU\TPU\pers\40080 | |
| 701 | 1 | |a Tverdokhlebov |b S. I. |c physicist |c Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science |f 1961- |g Sergei Ivanovich |3 (RuTPU)RU\TPU\pers\30855 |9 15101 | |
| 701 | 1 | |a Filimonov |b V. D. |c Russian chemist |c Professor of the TPU |f 1945- |g Viktor Dmitrievich |3 (RuTPU)RU\TPU\pers\26423 |9 12127 | |
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