A new approach for the immobilization of poly(acrylic) acid as a chemically reactive cross-linker on the surface of poly(lactic) acid-based biomaterials

A new approach for the immobilization of poly(acrylic) acid as a chemically reactive cross-linker on the surface of poly(lactic) acid-based biomaterials

Bibliographic Details
Parent link:	Materials Science and Engineering: C.— , 1993- Vol. 71.— 2017.— [P. 862–869]
Corporate Authors:	Национальный исследовательский Томский политехнический университет (ТПУ) Институт физики высоких технологий (ИФВТ) Кафедра биотехнологии и органической химии (БИОХ), Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Кафедра экспериментальной физики (ЭФ)
Other Authors:	Stankevich K. S. Ksenia Sergeevna, Danilenko N. V. Nadezhda Viktorovna, Gadirov R. M. Ruslan Mukhamedzhanovich, Goreninsky (Goreninskii) S. I. Semen Igorevich, Tverdokhlebov S. I. Sergei Ivanovich, Filimonov V. D. Viktor Dmitrievich
Summary:	Title screen A new approach for the immobilization of poly(acrylic) acid (PAA) as a chemically reactive cross-linker on thesurface of poly(lactic) acid-based (PLA) biomaterials is described. The proposed technique includes noncovalentattachment of a PAA layer to the surface of PLA-based biomaterial via biomaterial surface treatmentwith solvent/non-solvent mixture followed by the entrapment of PAA from its solution. Surface morphologyand wettability of the obtained PLA-PAA composite materials were investigated by AFM and the sitting dropmethod respectively. The amount of the carboxyl groups on the composites surface was determined by usingthe fluorescent compounds (2-(5-aminobenzo[d]oxazol-2-yl)phenol (ABO) and its acyl derivative N-(2-(2-hydroxyphenyl)benzo[d]oxazol-5-yl)acetamide (AcABO)). It was shown that it is possible to obtain PLA-PAAcomposites with various surface relief and tunable wettability (57C, 62C and 66C). The capacity of the createdPAA layer could be varied from 1.5 nmol/cm2 to 0.1 µmol/cm2 depending on the modification conditions. Additionally,using bovine serum albumin (BSA) it was demonstrated that such composites could be modified withproteins with high binding density (around 0.18 nmol/cm2). Obtained fluoro-labeled PLA-PAA materials, aswell as PLA-PAA composites themselves, are valuable since they can be used for biodegradable polymer implantstracking in living systems and as drug delivery systems. Режим доступа: по договору с организацией-держателем ресурса
Published:	2017
Subjects:	электронный ресурс труды учёных ТПУ poly(lactic) acid poly(acrylic) acid surface modification entrapment composite materials fluorescent compounds bovine serum albumin полимолочная кислота полиакриловая кислота поверхности модификации защемления композиционные материалы флуоресцентные соединения
Online Access:	http://dx.doi.org/10.1016/j.msec.2016.10.078
Format:	Electronic Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=653223

Internet

http://dx.doi.org/10.1016/j.msec.2016.10.078