Comparison of the Influence of "Solvent/Non-Solvent” Treatment for the Attachment of Signal Molecules on the Structure of Electrospun PCL and PLLA Biodegradable Scaffolds

Comparison of the Influence of "Solvent/Non-Solvent” Treatment for the Attachment of Signal Molecules on the Structure of Electrospun PCL and PLLA Biodegradable Scaffolds

Bibliographic Details
Parent link:MATEC Web of Conferences
Vol. 79 : Information-Measuring Equipment and Technologies (IME&T 2016).— 2016.— [01025, 8 p.]
Corporate Authors: Национальный исследовательский Томский политехнический университет (ТПУ) Институт неразрушающего контроля (ИНК) Кафедра физических методов и приборов контроля качества (ФМПК), Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Кафедра экспериментальной физики (ЭФ), Национальный исследовательский Томский политехнический университет (ТПУ) Управление проректора по научной работе и инновациям (НРиИ) Центр RASA в Томске (Центр RASA) Лаборатория изучения механизмов сигнальной трансдукции (Лаб. ИМСТ), Национальный исследовательский Томский политехнический университет (ТПУ) Институт физики высоких технологий (ИФВТ) Кафедра биотехнологии и органической химии (БИОХ)
Other Authors: Goreninsky (Goreninskii) S. I. Semen Igorevich, Stankevich K. S. Ksenia Sergeevna, Bolbasov E. N. Evgeny Nikolaevich, Danilenko N. V. Nadezhda Viktorovna, Filimonov V. D. Viktor Dmitrievich, Tverdokhlebov S. I. Sergei Ivanovich
Summary:Title screen
Electrospun biodegradable scaffolds (matrixes) made of poly([epsilon]-caprolactone) (PCL) and poly(L-lactic acid) (PLLA) are three-dimensional fibrous structures that are commonly used in regenerative medicine and drug delivery systems. Modification of such structures allows manipulating with biological and immune response. Previously, our team suggested a number of surface modification strategies for thin films made of PLLA. One of the proposed strategies are based on treatment of the material with “solvent/non-solvent” mixture that allows absorbing biologically active molecules or linkers on the surface of the sample. The aim of this work was to compare the influence of “solvent/non-solvent” treatment on the structure and crystallinity of the elecrospun biodegradable PCL and PLLA scaffolds. For that purpose, original PCL and PLLA scaffolds were treated with mixture of toluene and ethanol in different proportions. Morphology of the obtained samples was studied using scanning electron microscopy. It was shown that “solvent/non-solvent” treatment doesn’t lead to changes in scaffolds morphology such as gluing or cutting of the matrix fibers. By means of X-ray diffraction analysis it was shown that treatment of the samples with selected mixtures doesn’t change material crystallinity. Thus, it was demonstrated that proposed composition of the “solvent/nonsolvent” mixture can be used for the modification of electrospun PCL and PLLA scaffolds.
Language:English
Published: 2016
Subjects:
электронный ресурс
труды учёных ТПУ
растворители
волокнистые структуры
регенеративная медицина
поверхности
тонкие пленки
нерастворители
сканирующая электронная микроскопия
кристалличность
имунные реакции
Online Access:http://dx.doi.org/10.1051/matecconf/20167901025
http://earchive.tpu.ru/handle/11683/35257
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=651528

Internet

http://dx.doi.org/10.1051/matecconf/20167901025
http://earchive.tpu.ru/handle/11683/35257

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