pHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue

PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue

Bibliographic Details
Parent link:RSC Advances.— , 2011-
Vol. 6, iss. 65.— 2016.— [P. 60196-60199]
Corporate Author: Национальный исследовательский Томский политехнический университет Институт физики высоких технологий Кафедра биотехнологии и органической химии
Other Authors: Demin A. M. Aleksandr Mikhaylovich, Pershina A. G. Aleksandra Gennadievna, Nevskaya K. V. Ksenia Vladimirovna, Efimova L. V. Lina Viktorovna, Shchegoleva N. N. Nina Nikiforovna, Uymin A. M. Alexandr Michaylovitch, Kuznetsov D. K. Dmitrii Konstantinovich, Shur V. Ya. Vladimir Yakovlevich, Krasnov V. P. Viktor Pavlovich, Ogorodova L. M. Lyudmila Mikhaylovna
Summary:Title screen
Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe3O4 magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.
Режим доступа: по договору с организацией-держателем ресурса
Published: 2016
Subjects:
электронный ресурс
труды учёных ТПУ
Online Access:http://dx.doi.org/10.1039/C6RA13178F
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=650722
Description
Summary:Title screen
Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe3O4 magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.
Режим доступа: по договору с организацией-держателем ресурса
DOI:10.1039/C6RA13178F

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