Transdermal delivery of xenon from lipophilic solution and water

Transdermal delivery of xenon from lipophilic solution and water

Bibliographic Details
Parent link:Dermatology Aspects
Vol. 3.— 2015.— [6 p.]
Corporate Authors: Национальный исследовательский Томский политехнический университет (ТПУ) Институт физики высоких технологий (ИФВТ) Кафедра биотехнологии и органической химии (БИОХ), Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Кафедра теоретической и экспериментальной физики (ТиЭФ)
Other Authors: Verkhovsky A. Yu. Aleksandr Yurjevich, Atochin D. N. Dmitry Nikolaevich, Udintsev S. N. Sergey Nikolaevich, Tverdokhlebov S. I. Sergei Ivanovich, Anfinogenova Ya. J. Yana Jonovna, Serebrov V. Yu. Vladimir Yurjevich
Summary:Title screen
Aim: The purpose of the study was to characterize transdermal delivery of xenon through rat skin from a lipophilic solution and from water.Methods: Sections of skin were obtained from adult rats (n=12) and were placed into static Franz diffusion cells for 24 h. Xenon diffusion coefficients were determined for diffusion from a lipophilic solution (n=6) and from water (n=6) to phosphate buffered saline (PBS) through skin and for diffusion from a lipophilic solution to PBS through a phase boundary in the absence of skin (n=6).Results: Xenon flux (JXe) through skin from the lipophilic solution was 0.036 mg/hour?cm2 and permeability coefficient (Kp) was 0.003 cm/h; JXe through skin from water was 0.029 mg/h?cm2 and the Kp was 0.002 cm/h. Total time for xenon diffusion through skin from lipophilic solution and from water was ~2 h.Conclusion: The study presents the first characterization of xenon diffusion through rat skin from multiphase solutions to PBS. These data may be useful for the development of xenon-rich pharmaceutical products for external use.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2015
Subjects:
электронный ресурс
труды учёных ТПУ
xenon
transdermal delivery
Online Access:http://dx.doi.org/10.7243/2053-5309-3-2
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=644096

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