Transdermal delivery of xenon from lipophilic solution and water
| Parent link: | Dermatology Aspects Vol. 3.— 2015.— [6 p.] |
|---|---|
| Corporate Authors: | , |
| Other Authors: | , , , , , |
| Summary: | Title screen Aim: The purpose of the study was to characterize transdermal delivery of xenon through rat skin from a lipophilic solution and from water.Methods: Sections of skin were obtained from adult rats (n=12) and were placed into static Franz diffusion cells for 24 h. Xenon diffusion coefficients were determined for diffusion from a lipophilic solution (n=6) and from water (n=6) to phosphate buffered saline (PBS) through skin and for diffusion from a lipophilic solution to PBS through a phase boundary in the absence of skin (n=6).Results: Xenon flux (JXe) through skin from the lipophilic solution was 0.036 mg/hour?cm2 and permeability coefficient (Kp) was 0.003 cm/h; JXe through skin from water was 0.029 mg/h?cm2 and the Kp was 0.002 cm/h. Total time for xenon diffusion through skin from lipophilic solution and from water was ~2 h.Conclusion: The study presents the first characterization of xenon diffusion through rat skin from multiphase solutions to PBS. These data may be useful for the development of xenon-rich pharmaceutical products for external use. Режим доступа: по договору с организацией-держателем ресурса |
| Language: | English |
| Published: |
2015
|
| Subjects: | |
| Online Access: | http://dx.doi.org/10.7243/2053-5309-3-2 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=644096 |