Transdermal delivery of xenon from lipophilic solution and water
| Parent link: | Dermatology Aspects Vol. 3.— 2015.— [6 p.] |
|---|---|
| Corporate Authors: | , |
| Drugi avtorji: | , , , , , |
| Izvleček: | Title screen Aim: The purpose of the study was to characterize transdermal delivery of xenon through rat skin from a lipophilic solution and from water.Methods: Sections of skin were obtained from adult rats (n=12) and were placed into static Franz diffusion cells for 24 h. Xenon diffusion coefficients were determined for diffusion from a lipophilic solution (n=6) and from water (n=6) to phosphate buffered saline (PBS) through skin and for diffusion from a lipophilic solution to PBS through a phase boundary in the absence of skin (n=6).Results: Xenon flux (JXe) through skin from the lipophilic solution was 0.036 mg/hour?cm2 and permeability coefficient (Kp) was 0.003 cm/h; JXe through skin from water was 0.029 mg/h?cm2 and the Kp was 0.002 cm/h. Total time for xenon diffusion through skin from lipophilic solution and from water was ~2 h.Conclusion: The study presents the first characterization of xenon diffusion through rat skin from multiphase solutions to PBS. These data may be useful for the development of xenon-rich pharmaceutical products for external use. Режим доступа: по договору с организацией-держателем ресурса |
| Jezik: | angleščina |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | http://dx.doi.org/10.7243/2053-5309-3-2 |
| Format: | Elektronski Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=644096 |
MARC
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| 200 | 1 | |a Transdermal delivery of xenon from lipophilic solution and water |f A. Yu. Verkhovsky [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 34 tit.] | ||
| 330 | |a Aim: The purpose of the study was to characterize transdermal delivery of xenon through rat skin from a lipophilic solution and from water.Methods: Sections of skin were obtained from adult rats (n=12) and were placed into static Franz diffusion cells for 24 h. Xenon diffusion coefficients were determined for diffusion from a lipophilic solution (n=6) and from water (n=6) to phosphate buffered saline (PBS) through skin and for diffusion from a lipophilic solution to PBS through a phase boundary in the absence of skin (n=6).Results: Xenon flux (JXe) through skin from the lipophilic solution was 0.036 mg/hour?cm2 and permeability coefficient (Kp) was 0.003 cm/h; JXe through skin from water was 0.029 mg/h?cm2 and the Kp was 0.002 cm/h. Total time for xenon diffusion through skin from lipophilic solution and from water was ~2 h.Conclusion: The study presents the first characterization of xenon diffusion through rat skin from multiphase solutions to PBS. These data may be useful for the development of xenon-rich pharmaceutical products for external use. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Dermatology Aspects | ||
| 463 | |t Vol. 3 |v [6 p.] |d 2015 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a xenon | |
| 610 | 1 | |a transdermal delivery | |
| 701 | 1 | |a Verkhovsky |b A. Yu. |g Aleksandr Yurjevich | |
| 701 | 1 | |a Atochin |b D. N. |c neuroscientist |c The Head of the Laboratory of Tomsk Polytechnic University |f 1960- |g Dmitry Nikolaevich |3 (RuTPU)RU\TPU\pers\37514 | |
| 701 | 1 | |a Udintsev |b S. N. |g Sergey Nikolaevich | |
| 701 | 1 | |a Tverdokhlebov |b S. I. |c physicist |c Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science |f 1961- |g Sergei Ivanovich |3 (RuTPU)RU\TPU\pers\30855 |9 15101 | |
| 701 | 1 | |a Anfinogenova |b Ya. J. |c Linguist |c Lecturer of Tomsk Polytechnic University, Doctor of medical sciences |f 1970- |g Yana Jonovna |3 (RuTPU)RU\TPU\pers\33592 | |
| 701 | 1 | |a Serebrov |b V. Yu. |c chemist |c Professor of Tomsk Polytechnic University, doctor of medical Sciences |f 1952- |g Vladimir Yurjevich |3 (RuTPU)RU\TPU\pers\35447 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет (ТПУ) |b Институт физики высоких технологий (ИФВТ) |b Кафедра биотехнологии и органической химии (БИОХ) |3 (RuTPU)RU\TPU\col\18693 |
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