Peculiarities of Adrenergic Regulation of Smooth Muscles in Rabbit Pulmonary Arteries; Bulletin of Experimental Biology and Medicine; Vol. 133, iss. 3
| Parent link: | Bulletin of Experimental Biology and Medicine: Scientific Journal Vol. 133, iss. 3.— 2002.— [P. 214-216] |
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| その他の著者: | , , , , , , |
| 要約: | Title screen Muscle tension recording was used to study adrenergic contractile reactions of pulmonary artery smooth muscles in rabbits. Stimulation of alpha-adrenoceptors induced contraction of pulmonary artery smooth muscle cells. Endothelium partially inhibited the contractile effect of alpha-adrenoceptor agonists. Activation of smooth muscle beta-adrenoceptors in pulmonary arteries produced a dual dose-dependent effect (relaxation at agonist concentrations of 10 nM-1 muM and contraction at concentrations above 10 muM). The contractile effect of beta-adrenoceptor activation in smooth muscle cells is a specific feature of pulmonary arteries probably related to peculiarities of cAMP-signaling in these cells. Режим доступа: по договору с организацией-держателем ресурса |
| 言語: | 英語 |
| 出版事項: |
2002
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| 主題: | |
| オンライン･アクセス: | http://link.springer.com/article/10.1023/A:1015862028565 |
| フォーマット: | MixedMaterials 電子媒体 図書の章 |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=639218 |
| 要約: | Title screen Muscle tension recording was used to study adrenergic contractile reactions of pulmonary artery smooth muscles in rabbits. Stimulation of alpha-adrenoceptors induced contraction of pulmonary artery smooth muscle cells. Endothelium partially inhibited the contractile effect of alpha-adrenoceptor agonists. Activation of smooth muscle beta-adrenoceptors in pulmonary arteries produced a dual dose-dependent effect (relaxation at agonist concentrations of 10 nM-1 muM and contraction at concentrations above 10 muM). The contractile effect of beta-adrenoceptor activation in smooth muscle cells is a specific feature of pulmonary arteries probably related to peculiarities of cAMP-signaling in these cells. Режим доступа: по договору с организацией-держателем ресурса |
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