Метод получения новых о-ацилоксимов триптантрина
| Parent link: | Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XVIII Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 27-30 апреля 2021 г./ Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой.— , 2021 Т. 2 : Химия.— 2021.— [С. 134-136] |
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| Summary: | Заглавие с экрана Earlier [1, 2], a number of new potential inhibitors of the JNK kinase isoform family (JNK1, JNK2, JNK3) were identified, which are involved in the pathogenesis of many cardiovascular, oncological and psychosomatic diseases. One of the potential inhibitors is tryptanthrin-6-oxime (Trp-Ox), which exhibit good pan-selectivity for JNK. However, most of the compounds had low solubility in water and organic solvents and high toxicity. This work presents the synthesis of new tryptanthrin O-acyloximes with the aim of increasing their activity and / or the selectivity of the obtained analogs with respect to JNK isoforms, their hydrophilic properties and expanding the library of nitrogen-containing heterocyclic compounds, which will also be of interest to researchers studying other type biological activity. |
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2021
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| Online Access: | http://earchive.tpu.ru/handle/11683/68297 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=633343 |