Модуляция окислительного стресса в антипаразитарной терапии инвазии Opisthorchis felineus
| Parent link: | Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XVII Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 21-24 апреля 2020 г./ Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой.— , 2020 Т. 4 : Биология и фундаментальная медицина.— 2020.— [67-69] |
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| Summary: | Заглавие с экрана The influence of oxidative stress caused by L-butionine-sulfoximine and hydrogen peroxide on the O. felineus mature forms viability and egg production was determined. Oxidative stress induced by H[2]O[2] at 125 [mu]M and 250 [mu]M did not affect the viability of O. felineus mature forms. Also, it caused a decrease in egg production. After the pre-incubation of O. felineus mature forms with inhibitor of the main antioxidant enzyme (glutathione) synthesis L-butionine-sulfoximine, the hydrogen peroxide leads to the marit cells death at lower concentrations of prooxidant (0.125 and 0.250 mM H[2]O[2]).Thus, [gamma]-glutamylcysteineligase inhibition by L-butionine-sulfoximine leads to an increase in the O. felineus mature forms sensitivity to exogenous reactive oxygen species, which makes it possible to consider this key glutathione synthesis enzyme as a promising potential therapeutic target in the opisthorchiasis treatment. |
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2020
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| Online Access: | http://earchive.tpu.ru/handle/11683/63008 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=631575 |