Влияние инсулин оподобного фактора роста 1 на патологические процессы в купризоновой модели рассеянного склероза; Перспективы развития фундаментальных наук; Т. 4 : Биология и фундаментальная медицина
| Parent link: | Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XIV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 25-28 апреля 2017 г./ Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой.— , 2017 Т. 4 : Биология и фундаментальная медицина.— 2017.— [С. 169-171] |
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| Summary: | Заглавие с экрана The study aimed to evaluate the effect of insulin-like growth factor 1 (IGF-1) on the cuprizone-induced murine model of demyelination and accompanying astrogliosis. Demyelination was induced in 14 adult male mice by 0.3% cuprizone in drinking water. Five animals from the cuprizone-teated group received subcutaneous injections of IGF-1. Seven animals were used as a control group. The extent of demyelination was evaluated as a decrease of the size of the corpus callosum on T2-weighted images that were received using 11.7T animal MRI scanner. Brain sections were immunohistochemically stained for glial fibrillary acidic protein (GFAP), a marker of astrocytes. It was revealed the cuprizone caused extensive demyelination and astroglyosis. IGF-1 treatment restored the size of corpus callosum and the number of astrocytes in corpus callosum and anterior commissure to the control level. |
| Sprog: | russisk |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | http://earchive.tpu.ru/handle/11683/44890 |
| Format: | MixedMaterials Electronisk Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=625100 |
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| 200 | 1 | |a Влияние инсулин оподобного фактора роста 1 на патологические процессы в купризоновой модели рассеянного склероза |d Effects of insulin-like growth factor 1 on pathologic process in the cuprizone model of multiple sclerosis |f Д. А. Федоришин |g науч. рук. М. Ю. Ходанович | |
| 203 | |a Текст |c электронный | ||
| 230 | |a 1 компьютерный файл (pdf; 248 Kb) | ||
| 300 | |a Заглавие с экрана | ||
| 320 | |a [Библиогр.: с. 171 (2 назв.)] | ||
| 330 | |a The study aimed to evaluate the effect of insulin-like growth factor 1 (IGF-1) on the cuprizone-induced murine model of demyelination and accompanying astrogliosis. Demyelination was induced in 14 adult male mice by 0.3% cuprizone in drinking water. Five animals from the cuprizone-teated group received subcutaneous injections of IGF-1. Seven animals were used as a control group. The extent of demyelination was evaluated as a decrease of the size of the corpus callosum on T2-weighted images that were received using 11.7T animal MRI scanner. Brain sections were immunohistochemically stained for glial fibrillary acidic protein (GFAP), a marker of astrocytes. It was revealed the cuprizone caused extensive demyelination and astroglyosis. IGF-1 treatment restored the size of corpus callosum and the number of astrocytes in corpus callosum and anterior commissure to the control level. | ||
| 461 | 1 | |0 (RuTPU)RU\TPU\conf\21388 |t Перспективы развития фундаментальных наук |l Prospects of Fundamental Sciences Development |o сборник научных трудов XIV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 25-28 апреля 2017 г. |o в 7 т. |f Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой |d 2017 | |
| 463 | 1 | |0 (RuTPU)RU\TPU\conf\21393 |t Т. 4 : Биология и фундаментальная медицина |v [С. 169-171] |d 2017 | |
| 510 | 1 | |a Effects of insulin-like growth factor 1 on pathologic process in the cuprizone model of multiple sclerosis |z eng | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a рассеянный склероз | |
| 610 | 1 | |a тестирование | |
| 610 | 1 | |a патологические процессы | |
| 610 | 1 | |a микрофотографии | |
| 610 | 1 | |a микроскопы | |
| 610 | 1 | |a интоксикация | |
| 700 | 1 | |a Федоришин |b Д. А. | |
| 702 | 1 | |a Ходанович |b М. Ю. |4 727 | |
| 801 | 2 | |a RU |b 63413507 |c 20171211 |g RCR | |
| 856 | 4 | |u http://earchive.tpu.ru/handle/11683/44890 | |
| 942 | |c BK | ||