Влияние инсулин оподобного фактора роста 1 на патологические процессы в купризоновой модели рассеянного склероза
| Parent link: | Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XIV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 25-28 апреля 2017 г./ Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой.— , 2017 Т. 4 : Биология и фундаментальная медицина.— 2017.— [С. 169-171] |
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| Summary: | Заглавие с экрана The study aimed to evaluate the effect of insulin-like growth factor 1 (IGF-1) on the cuprizone-induced murine model of demyelination and accompanying astrogliosis. Demyelination was induced in 14 adult male mice by 0.3% cuprizone in drinking water. Five animals from the cuprizone-teated group received subcutaneous injections of IGF-1. Seven animals were used as a control group. The extent of demyelination was evaluated as a decrease of the size of the corpus callosum on T2-weighted images that were received using 11.7T animal MRI scanner. Brain sections were immunohistochemically stained for glial fibrillary acidic protein (GFAP), a marker of astrocytes. It was revealed the cuprizone caused extensive demyelination and astroglyosis. IGF-1 treatment restored the size of corpus callosum and the number of astrocytes in corpus callosum and anterior commissure to the control level. |
| Language: | Russian |
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2017
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| Online Access: | http://earchive.tpu.ru/handle/11683/44890 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=625100 |