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|a (RuTPU)RU\TPU\conf\21210
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|a RU\TPU\conf\21209
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|a 622481
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|a 20170412d2016 k y0rusy50 ba
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|a eng
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| 102 |
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|a RU
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| 135 |
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|a drgn ---uucaa
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| 181 |
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|a i
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| 182 |
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|a b
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| 200 |
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|a Developing an underwater robot control system
|f E. S. Kazantseva, D. M. Аbdrakhmanova
|g sci. adv. A. I. Khlebnikov
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| 203 |
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|a Текст
|c электронный
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| 300 |
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|a Заглавие с экрана
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| 320 |
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|a [Библиогр.: с. 252 (4 назв.)]
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| 330 |
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|a This work is aimed at creating a synthetic analog of the human interleukin-4 (IL-4) which will be used for coating the surface of biomaterials based on biodegradable polymers (polylactic acid, polycaprolactone) in order to impart immunomodulatory properties and increase biocompatibility. Molecule-analogue is designed based on knowledge of the crystal structure of the ligand receptor complex (IL-4 / IL-4 R-1 / IL-4-R2). Our approach involves identifying specific sites of interaction between IL-4 and IL-4-R1 and, from the above, forecast the possible structure of the analogues of IL-4. The interaction between the proposed analogs and receptors of IL-4-R1 is estimated using computational methods such as molecular docking and molecular dynamics, which allow to determine the degree of structural complementarity synthetic analogue to a receptor Analysis has been performed and 4-[N-allyl-N-(4-f rmylphenyl)amino]benzaldehyde is a molecule, which most likely will lead to the assembly of the complex of IL-4 / IL-4-R1.
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| 463 |
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1 |
|0 (RuTPU)RU\TPU\conf\18763
|t Ресурсоэффективным технологиям - энергию и энтузиазм молодых
|o сборник научных трудов VII Всероссийской конференции, г. Томск, 27-29 апреля 2016 г.
|f Национальный исследовательский Томский политехнический университет (ТПУ)
|v [С. 251-252]
|d 2016
|
| 610 |
1 |
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|a труды учёных ТПУ
|
| 610 |
1 |
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|a электронный ресурс
|
| 610 |
1 |
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|a синтетические вещества
|
| 610 |
1 |
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|a аналоги
|
| 610 |
1 |
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|a дифениламин
|
| 610 |
1 |
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|a биоматериалы
|
| 610 |
1 |
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|a биоразлагаемые полимеры
|
| 700 |
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1 |
|a Kazantseva
|b E. S.
|
| 701 |
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1 |
|a Аbdrakhmanova
|b D. M.
|
| 702 |
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1 |
|a Khlebnikov
|b A. I.
|c Chemist
|c Professor of Tomsk Polytechnic University
|f 1963-
|g Andrey Ivanovich
|4 727
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| 712 |
0 |
2 |
|a Национальный исследовательский Томский политехнический университет (ТПУ)
|b Институт физики высоких технологий (ИФВТ)
|b Кафедра биотехнологии и органической химии (БИОХ)
|3 (RuTPU)RU\TPU\col\18693
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| 801 |
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2 |
|a RU
|b 63413507
|c 20170427
|g RCR
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| 856 |
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|u http://earchive.tpu.ru/handle/11683/38095
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| 942 |
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|c CF
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