Developing an underwater robot control system
| Parent link: | Ресурсоэффективным технологиям - энергию и энтузиазм молодых.— 2016.— [С. 251-252] |
|---|---|
| 1. autor: | |
| Korporacja: | |
| Kolejni autorzy: | , |
| Streszczenie: | Заглавие с экрана This work is aimed at creating a synthetic analog of the human interleukin-4 (IL-4) which will be used for coating the surface of biomaterials based on biodegradable polymers (polylactic acid, polycaprolactone) in order to impart immunomodulatory properties and increase biocompatibility. Molecule-analogue is designed based on knowledge of the crystal structure of the ligand receptor complex (IL-4 / IL-4 R-1 / IL-4-R2). Our approach involves identifying specific sites of interaction between IL-4 and IL-4-R1 and, from the above, forecast the possible structure of the analogues of IL-4. The interaction between the proposed analogs and receptors of IL-4-R1 is estimated using computational methods such as molecular docking and molecular dynamics, which allow to determine the degree of structural complementarity synthetic analogue to a receptor Analysis has been performed and 4-[N-allyl-N-(4-f rmylphenyl)amino]benzaldehyde is a molecule, which most likely will lead to the assembly of the complex of IL-4 / IL-4-R1. |
| Język: | angielski |
| Wydane: |
2016
|
| Hasła przedmiotowe: | |
| Dostęp online: | http://earchive.tpu.ru/handle/11683/38095 |
| Format: | Elektroniczne Rozdział |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=622481 |
| Streszczenie: | Заглавие с экрана This work is aimed at creating a synthetic analog of the human interleukin-4 (IL-4) which will be used for coating the surface of biomaterials based on biodegradable polymers (polylactic acid, polycaprolactone) in order to impart immunomodulatory properties and increase biocompatibility. Molecule-analogue is designed based on knowledge of the crystal structure of the ligand receptor complex (IL-4 / IL-4 R-1 / IL-4-R2). Our approach involves identifying specific sites of interaction between IL-4 and IL-4-R1 and, from the above, forecast the possible structure of the analogues of IL-4. The interaction between the proposed analogs and receptors of IL-4-R1 is estimated using computational methods such as molecular docking and molecular dynamics, which allow to determine the degree of structural complementarity synthetic analogue to a receptor Analysis has been performed and 4-[N-allyl-N-(4-f rmylphenyl)amino]benzaldehyde is a molecule, which most likely will lead to the assembly of the complex of IL-4 / IL-4-R1. |
|---|