Химические элементы при тиреоидных патологиях
| Parent link: | Геохимия живого вещества: международная молодежная школа-семинар, посвященная 150-летию со дня рождения В. И. Вернадского (1863-2013), Томск, 2-5 июня 2013 г./ Национальный исследовательский Томский политехнический университет (ТПУ) [и др.]. [С. 61-64].— , 2013 |
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| Summary: | Заглавие с титульного листа The research material is a database of the Tomsk regional about 18 500 patients with various diseases of a thyroid gland. We analyzed contents of 24 elements (Na, Ca, Sc, Cr, Fe, Co, Zn, Br, Rb, Ag, Sb, Au, La, Th, U, Hf, Se, Hg, Ce, Sm, Eu, Yb, and Lu) in thyroid tissue by the analysis of neutron activation. The region zoning of the territory has been made according to the level of morbidity. The thyroid pathology in Tomskregion has no clear associations with iodine level in environments. We revealed that development of the thyroid gland pathology depend on ecological and geochemical factors (a close locating to industrial net of Tomsk, cold climate). We have identified a deficiency of selenium in thyroid cancer (1,49±0,16 mg/kg) where the concentration is significantly lower compared to the control (2,8±0,27 mg/kg) and nodular goiter (1,69±0,14 mg/kg) (p = 0,03). Selenium deficiency in pathological thyroid tissue occurs with increased accumulation of sodium, iron, bromine, rubidium, samarium, mercury, low calcium. Correlation analysis revealed positive relationships between the elements Co, Cr, Fe, Zn, Sc (r 0,2-0,6; p < 0,01; Sm, Au, La, Ca, Sb, U (r 0,3-0,5; p < 0,05-0,01), Na and Rb (r = +0,5; p < 0,01); negative relation with Ca Na, Rb, Br (r 0,3-0,5, p < 0,01. The association of chemical elements can be explained by a common source of income (enterprise of the nuclear fuel cycle, petroleum industry). Features of trace element composition in the thyroid gland primarily reflect the impact of technogenic factors. The mechanism may be associated with imbalances of trace elements. Deficiency of iodine and selenium leads to the accumulation of non-essential elements of thyroid tissue, which may contribute to autoimmune processes and the formation of goiter |
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2013
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| Online Access: | http://www.lib.tpu.ru/fulltext/c/2013/C32/007.pdf |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=242194 |