Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery
| 企業作者: | |
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| 其他作者: | , |
| 總結: | XVII, 453 p. 109 illus., 91 illus. in color. text |
| 語言: | 英语 |
| 出版: |
New York, NY :
Springer US : Imprint: Humana,
2021.
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| 版: | 1st ed. 2021. |
| 叢編: | Methods in Pharmacology and Toxicology,
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| 主題: | |
| 在線閱讀: | https://doi.org/10.1007/978-1-0716-1250-7 |
| 格式: | 電子 圖書 |
書本目錄:
- Measurement of Transcellular Transport Rates and Intracellular Drug Sequestration in the Presence of an Extracellular Concentration Gradient
- Kinetic Design for Establishing Long Term Stationary Cytosol Concentrations during Drug Transport across P-gp Expressing Confluent Cell Monolayers to Facilitate Measuring Cytosol Concentration, Fitting Drug Molar Partition Coefficients into the Cytosolic Monolayer of the Plasma Membrane and Kinetically Identifying Drug Uptake Transporters
- In Vitro Methodologies to Assess Potential for Transporter-Mediated Drug-Drug Interactions
- Determination of Fraction Unbound and Unbound Partition Coefficient to Estimate Intracellular Free Drug Concentration
- Quantitative Analysis of Intracellular Drug Concentrations in Hepatocytes
- Quantification of Intracellular Drug Aggregates and Precipitates
- Quantitative Phenotypic Analysis of Drug Sequestering Macrophage Subpopulations
- Using an Integrated QSAR Model to Check Whether Small-Molecule Xenobiotics Will Accumulate in Biomembranes, with Particular Reference to Fluorescent Imaging Probes
- Diversity-Oriented Fluorescence Library Approach (DOFLA) for Discovery of Cell-Permeable Probes for Applications in Live Cell Imaging
- Overcoming Cellular and Systemic Barriers to Design the Next Wave of Peptide Therapeutics
- Intracellular Targeting of Cyclotides for Therapeutic Applications
- Cellular Trafficking of Monoclonal and Bispecific Antibodies
- Quantitative Drug Target Imaging Using Paired-Agent Principles
- Quantitative Determination of Intracellular Bond Cleavage
- Development and Application of a Single Cell-Level PK-PD Model for ADCs
- Contribution of Non-Target Cells to the Disposition, Antitumor Activity, and Antigen-Independent Toxicity of Antibody Drug-Conjugates
- Tracking siRNA-Nanocarrier Assembly and Disassembly Using FRET
- Sub-Cellular Drug Depots as Reservoirs for Small Molecule Drugs.