Process for Producing 177Lu Solutions by Irradiation at the IRT-T Reactor, Followed by Gradient Elution; Radiochemistry; Vol. 68, iss. 2

Process for Producing 177Lu Solutions by Irradiation at the IRT-T Reactor, Followed by Gradient Elution; Radiochemistry; Vol. 68, iss. 2

Bibliographic Details
Parent link:Radiochemistry=Радиохимия.— .— New York: Pleiades Publishing, Inc.
Vol. 68, iss. 2.— 2026.— P. 174-180
Corporate Author: Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий
Other Authors: Ushakov I. A. Ivan Alekseevich, Zukau V. V. Valery Viktorovich, Makarov V. S, Vladimir Stanislavovich, Kazakov A. G. Andrey Gennadjevich, Ekatova T. Yu. Taisiya Yurjevna
Summary:Title screen
177Lu is one of the most widely used therapeutic radionuclides in nuclear medicine. The most promising procedure for its production is isolation from neutron-irradiated ytterbium targets enriched in 176Yb. Today, 177Lu is produced in the world at ten reactors, whereas the demand for this radionuclide steadily increases. In this study, a procedure was developed for producing 177Lu at the IRT-T research reactor (Tomsk, Russia) using ion-exchange chromatography with the column heating and elution with an α-HIBA solution with gradient рН. Conditions were found for producing a no-carrier-added 177Lu solution from ytterbium of natural isotope composition. The procedure was tested with an enriched ytterbium target. The 177Lu solutions obtained meets the requirements of the Russian Federation Pharmacopoeia. The process developed will be used for producing 177Lu at the IRT-T reactor for use in nuclear therapy
Текстовый файл
AM_Agreement
Language:English
Published: 2026
Subjects:
lutetium-177
irradiation
IRT-T reactor
ion-exchange chromatography
gradient elution
электронный ресурс
труды учёных ТПУ
Online Access:https://doi.org/10.1134/S1066362226020086
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=688672

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