Comparative study of anti-inflammatory and analgesic activity of diterpene alkaloid songorine obtained from Aconitum barbatum and its cell culture; Research Results in Pharmacology; Vol. 11 No. 4
| Parent link: | Research Results in Pharmacology.— .— Белгород: БелГУ Vol. 11 No. 4.— 2025.— P. 140-154 |
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| Erakunde egilea: | |
| Beste egile batzuk: | , , , , , , , |
| Gaia: | Title screen analgesic activities of diterpene alkaloid songorine obtained from Aconitum barbatumand its cell culture.Materials and Methods:Experiments were performed on 60 male mice of the CBA line. The object of the study was the diterpene alkaloid of songorine (25 μg/kg) isolated from Aconitum barbatum, as well as obtained from the callus culture of cells. Comparative study of analgesic and anti-inflammatory activities of the alkaloid obtained from different sources was carried out under conditions of the formalin test and abdominal constriction test. Diclofenac sodium(10 mg/kg) and paracetamol(85 mg/kg) were used as comparison drugs. Control animals received distilled water. All substances were administered to mice per osfor 5 days, the last time –1 hour before the onset of the damaging effect.Results and Discussion:Under the formalin test conditions, the analgesic activity of songorine from both sources was manifested in the second phase of pain response. The anti-inflammatory activity in this model of both “standard” and ”culture” songorine was comparable to that of diclofenac sodium. Probably, pharmacological activity of alkaloid in the formalin test is provided by suppression of proinflammatory mediators and TRPA1-receptors. In the abdominal constriction test, all investigated substances showed a pronounced analgesic effect maximum under the action of songorine in vitro.In addition, songorine from both sources, in contrast to the reference drug, provided a reliable phlogolytic effect. Probably, the pharmacological activity of songorine in this model is provided by its suppressive action against endogenous mediators of pain and inflammation and of TRPV1-receptors.Conclusion:Comparative analysis of the analgesic and anti-inflammatory effects of songorine (25 μg/kg) from Aconitum barbatumafter a 5-dose regimen demonstrated comparability with “culture” songorine (25 μg/kg) Текстовый файл |
| Hizkuntza: | ingelesa |
| Argitaratua: |
2025
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| Gaiak: | |
| Sarrera elektronikoa: | https://doi.org/10.18413/rrpharmacology.11.647 |
| Formatua: | Baliabide elektronikoa Liburu kapitulua |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=687698 |
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| 200 | 1 | |a Comparative study of anti-inflammatory and analgesic activity of diterpene alkaloid songorine obtained from Aconitum barbatum and its cell culture |f Yu. V. Nesterova, A. P. Chernova, T. N. Povetyeva [et al.] | |
| 203 | |a Текст |c электронный |b визуальный | ||
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| 300 | |a Title screen | ||
| 330 | |a analgesic activities of diterpene alkaloid songorine obtained from Aconitum barbatumand its cell culture.Materials and Methods:Experiments were performed on 60 male mice of the CBA line. The object of the study was the diterpene alkaloid of songorine (25 μg/kg) isolated from Aconitum barbatum, as well as obtained from the callus culture of cells. Comparative study of analgesic and anti-inflammatory activities of the alkaloid obtained from different sources was carried out under conditions of the formalin test and abdominal constriction test. Diclofenac sodium(10 mg/kg) and paracetamol(85 mg/kg) were used as comparison drugs. Control animals received distilled water. All substances were administered to mice per osfor 5 days, the last time –1 hour before the onset of the damaging effect.Results and Discussion:Under the formalin test conditions, the analgesic activity of songorine from both sources was manifested in the second phase of pain response. The anti-inflammatory activity in this model of both “standard” and ”culture” songorine was comparable to that of diclofenac sodium. Probably, pharmacological activity of alkaloid in the formalin test is provided by suppression of proinflammatory mediators and TRPA1-receptors. In the abdominal constriction test, all investigated substances showed a pronounced analgesic effect maximum under the action of songorine in vitro.In addition, songorine from both sources, in contrast to the reference drug, provided a reliable phlogolytic effect. Probably, the pharmacological activity of songorine in this model is provided by its suppressive action against endogenous mediators of pain and inflammation and of TRPV1-receptors.Conclusion:Comparative analysis of the analgesic and anti-inflammatory effects of songorine (25 μg/kg) from Aconitum barbatumafter a 5-dose regimen demonstrated comparability with “culture” songorine (25 μg/kg) | ||
| 336 | |a Текстовый файл | ||
| 461 | 1 | |t Research Results in Pharmacology |c Белгород |n БелГУ | |
| 463 | 1 | |t Vol. 11 No. 4 |v P. 140-154 |d 2025 | |
| 610 | 1 | |a diterpene alkaloid | |
| 610 | 1 | |a songorine | |
| 610 | 1 | |a Aconitum barbatum | |
| 610 | 1 | |a anti-inflammatory | |
| 610 | 1 | |a analgesic activity | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Nesterova |b Yu. V. |c Ecologist |c Engineer of Tomsk Polytechnic University |f 1980- |g Yulia Vladimirovna |9 21335 | |
| 701 | 1 | |a Chernova |b A. P. |c chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of chemical sciences |f 1984- |g Anna Pavlovna |9 22278 | |
| 701 | 1 | |a Povetjeva |b T. N. |g Tatjyana Nikolaevna | |
| 701 | 1 | |a Suslov |b N. I. |g Nikolay Innokentjevich | |
| 701 | 1 | |a Zyuzkov |b G. N. |g Gleb Nikolaevich | |
| 701 | 1 | |a Afanasjeva |b O. G. |g Olga Gennadjevna | |
| 701 | 1 | |a Kulpin |b P. V. |g Pavel Valerjevich | |
| 701 | 1 | |a Zhdanov |b V. V. |g Vadim Vadimovich | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Инженерная школа природных ресурсов |c (2017- ) |9 28300 |
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