Tailorable Antibacterial Activity and Biofilm Eradication Properties of Biocompatible α-Hydroxy Acid-Based Deep Eutectic Solvents; Pharmaceutics; Vol. 18, iss. 1
| Parent link: | Pharmaceutics.— .— Basel: MDPI AG Vol. 18, iss. 1.— 2026.— Article number 16, 25 p. |
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| Altri autori: | , , , , , , , , , |
| Riassunto: | Title screen Background/Objectives: Deep eutectic solvents (DESs) have recently gained attention for their antimicrobial properties, particularly because they target both planktonic bacteria and biofilms. Among these, DESs based on α-hydroxy acids (αHAs) are of interest due to their inherent antibacterial properties and favorable biocompatibility. However, effects of the αHA molecular structure and hydrogen bonding ability within a DES formulation on biological activity has not yet been thoroughly investigated. Methods: This study systematically investigates DESs formed by combining glycolic acid, lactic acid or tartaric acid with either choline chloride or tetraethylammonium chloride. Results: All DESs demonstrate broad-spectrum antibacterial activity against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa and effectively inhibit biofilm formation while exhibiting low cytotoxicity toward 3T3-L1 fibroblasts. Conclusions: DES formation enhances antibacterial efficacy while attenuating cytotoxicity compared to the individual components, thereby decoupling bactericidal activity from toxicity. Physicochemical characterization confirms the formation of a eutectic phase and reveals that biological activity is primarily governed by acidity rather than by the specific αHA structure or eutectic strength. These results provide new insights into structure-function relationships in DESs and establish a design strategy for biocompatible, non-cytotoxic antimicrobial agents Текстовый файл |
| Lingua: | inglese |
| Pubblicazione: |
2026
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| Soggetti: | |
| Accesso online: | https://doi.org/10.3390/pharmaceutics18010016 |
| Natura: | Elettronico Capitolo di libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=687220 |
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| 200 | 1 | |a Tailorable Antibacterial Activity and Biofilm Eradication Properties of Biocompatible α-Hydroxy Acid-Based Deep Eutectic Solvents |f Gleb Dubinenko, Elena Senkina, Ksenia Golovina [et al.] | |
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| 330 | |a Background/Objectives: Deep eutectic solvents (DESs) have recently gained attention for their antimicrobial properties, particularly because they target both planktonic bacteria and biofilms. Among these, DESs based on α-hydroxy acids (αHAs) are of interest due to their inherent antibacterial properties and favorable biocompatibility. However, effects of the αHA molecular structure and hydrogen bonding ability within a DES formulation on biological activity has not yet been thoroughly investigated. Methods: This study systematically investigates DESs formed by combining glycolic acid, lactic acid or tartaric acid with either choline chloride or tetraethylammonium chloride. Results: All DESs demonstrate broad-spectrum antibacterial activity against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa and effectively inhibit biofilm formation while exhibiting low cytotoxicity toward 3T3-L1 fibroblasts. Conclusions: DES formation enhances antibacterial efficacy while attenuating cytotoxicity compared to the individual components, thereby decoupling bactericidal activity from toxicity. Physicochemical characterization confirms the formation of a eutectic phase and reveals that biological activity is primarily governed by acidity rather than by the specific αHA structure or eutectic strength. These results provide new insights into structure-function relationships in DESs and establish a design strategy for biocompatible, non-cytotoxic antimicrobial agents | ||
| 336 | |a Текстовый файл | ||
| 461 | 1 | |t Pharmaceutics |c Basel |n MDPI AG | |
| 463 | 1 | |t Vol. 18, iss. 1 |v Article number 16, 25 p. |d 2026 | |
| 610 | 1 | |a электронный ресурс | |
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| 610 | 1 | |a deep eutectic solvents | |
| 610 | 1 | |a α-hydroxy acids | |
| 610 | 1 | |a quaternary ammonium compounds | |
| 610 | 1 | |a choline chloride | |
| 610 | 1 | |a tetraethylammonium chloride | |
| 610 | 1 | |a antibacterial | |
| 610 | 1 | |a antibiofilm | |
| 701 | 1 | |a Dubinenko |b G. E. |c Specialist in the field of material science |c Engineer of Tomsk Polytechnic University |f 1992- |g Gleb Evgenjevich |9 21551 | |
| 701 | 1 | |a Senkina |b E. I. |g Elena Ivanovna | |
| 701 | 1 | |a Golovina |b K. A. |g Kseniya Aleksandrovna | |
| 701 | 1 | |a Myshova |b A. E. |g Aleksandra Evgenjevna | |
| 701 | 1 | |a Igumnova |b O. A. |g Olga Alekseevna | |
| 701 | 1 | |a Plotnikov |b E. V. |c chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences |f 1983- |g Evgeny Vladimirovich |9 16417 | |
| 701 | 1 | |a Badaraev |b A. D. |c Physicist |c Engineer of Tomsk Polytechnic University |f 1995- |g Arsalan Dorzhievich |9 22441 | |
| 701 | 1 | |a Rutkowski |b S. |c chemist |c Research Engineer, Tomsk Polytechnic University, Ph.D |f 1981- |g Sven |9 22409 | |
| 701 | 1 | |a Filimonov |b V. D. |c Russian chemist |c Professor of the TPU |f 1945- |g Viktor Dmitrievich |9 12127 | |
| 701 | 1 | |a Tverdokhlebov |b S. I. |c physicist |c Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science |f 1961- |g Sergei Ivanovich |9 15101 | |
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