Immobilization of Hydroxyapatite on the Surface of Porous Piezoelectric Fluoropolymer Implants for the Improved Stem Cell Adhesion and Osteogenic Differentiation; Surfaces; Vol. 9, iss. 1

Immobilization of Hydroxyapatite on the Surface of Porous Piezoelectric Fluoropolymer Implants for the Improved Stem Cell Adhesion and Osteogenic Differentiation; Surfaces; Vol. 9, iss. 1

Bibliografiska uppgifter
Parent link:Surfaces.— .— Basel: MDPI AG
Vol. 9, iss. 1.— 2026.— Article number 13, 15 p.
Övriga upphovsmän: Vorobjev A. O. Aleksandr Olegovich, Akimchenko I. O. Igor Olegovich, Mukhametshin A. Anton, Konoplyannikov M. A. Mikhail Anatoljevich, Efremov Yu. M., Timashev P. S., Zvyagin A. V. Andrey Vasiljevich, Bolbasov E. N. Evgeny Nikolaevich, Goreninsky (Goreninskii) S. I. Semen Igorevich
Sammanfattning:Title screen
Owing to their high strength characteristics, chemical stability, and piezoelectric activity, vinylidene fluoride (VDF) copolymers have become promising materials for creating implants to replace bone tissue defects. However, a significant drawback of these materials is the biological inertness of their surface, which leads to unsatisfactory integration with the patient’s bone tissue. In this study, we propose a single-step approach for immobilizing hydroxyapatite (HAp) on the surface of porous implants made of vinylidene fluoride and tetrafluoroethylene copolymer (P(VDF-TeFE)). This method consists of treating the surface of the product with a mixture of solvents while simultaneously capturing HAp microparticles. Using scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS), it was shown that the proposed method preserves the morphology of model implants (pore diameter and printed line thickness) and allows HAp to cover up to 63 ± 14% of their surface, reaching concentrations of calcium and phosphorus up to 6.0 ± 1.3 and 3.6 ± 0.7 at. %, respectively, imparting superhydrophilic properties to them. Optical profilometry revealed that the surface roughness of samples increased by more than seven times as a result of HAp immobilization. X-ray diffraction analysis (XRD) confirmed that the piezoelectric phase of P(VDF-TeFE) is preserved after treatment, as are the compressive strength characteristics of the samples. Hydroxyapatite immobilization significantly improved the adhesion and osteogenic differentiation of multipotent stem cells cultured with P(VDF-TeFE)-based samples. Thus, the proposed method can significantly enhance the biological activity of implants based on the piezoelectric VDF copolymer
Текстовый файл
Språk:engelska
Publicerad: 2026
Ämnen:
электронный ресурс
труды учёных ТПУ
hydroxyapatite
vinylidene fluoride
surface modification
bone implants
cell adhesion
Länkar:https://doi.org/10.3390/surfaces9010013
Materialtyp: Elektronisk Bokavsnitt
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=686478

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