Immobilization of Hydroxyapatite on the Surface of Porous Piezoelectric Fluoropolymer Implants for the Improved Stem Cell Adhesion and Osteogenic Differentiation; Surfaces; Vol. 9, iss. 1
| Parent link: | Surfaces.— .— Basel: MDPI AG Vol. 9, iss. 1.— 2026.— Article number 13, 15 p. |
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| Diğer Yazarlar: | , , , , , , , , |
| Özet: | Title screen Owing to their high strength characteristics, chemical stability, and piezoelectric activity, vinylidene fluoride (VDF) copolymers have become promising materials for creating implants to replace bone tissue defects. However, a significant drawback of these materials is the biological inertness of their surface, which leads to unsatisfactory integration with the patient’s bone tissue. In this study, we propose a single-step approach for immobilizing hydroxyapatite (HAp) on the surface of porous implants made of vinylidene fluoride and tetrafluoroethylene copolymer (P(VDF-TeFE)). This method consists of treating the surface of the product with a mixture of solvents while simultaneously capturing HAp microparticles. Using scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS), it was shown that the proposed method preserves the morphology of model implants (pore diameter and printed line thickness) and allows HAp to cover up to 63 ± 14% of their surface, reaching concentrations of calcium and phosphorus up to 6.0 ± 1.3 and 3.6 ± 0.7 at. %, respectively, imparting superhydrophilic properties to them. Optical profilometry revealed that the surface roughness of samples increased by more than seven times as a result of HAp immobilization. X-ray diffraction analysis (XRD) confirmed that the piezoelectric phase of P(VDF-TeFE) is preserved after treatment, as are the compressive strength characteristics of the samples. Hydroxyapatite immobilization significantly improved the adhesion and osteogenic differentiation of multipotent stem cells cultured with P(VDF-TeFE)-based samples. Thus, the proposed method can significantly enhance the biological activity of implants based on the piezoelectric VDF copolymer Текстовый файл |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
2026
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| Konular: | |
| Online Erişim: | https://doi.org/10.3390/surfaces9010013 |
| Materyal Türü: | Elektronik Kitap Bölümü |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=686478 |
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| 200 | 1 | |a Immobilization of Hydroxyapatite on the Surface of Porous Piezoelectric Fluoropolymer Implants for the Improved Stem Cell Adhesion and Osteogenic Differentiation |f Alexander Vorobyev, Igor Akimchenko, Anton Mukhamedshin [et al.] | |
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| 330 | |a Owing to their high strength characteristics, chemical stability, and piezoelectric activity, vinylidene fluoride (VDF) copolymers have become promising materials for creating implants to replace bone tissue defects. However, a significant drawback of these materials is the biological inertness of their surface, which leads to unsatisfactory integration with the patient’s bone tissue. In this study, we propose a single-step approach for immobilizing hydroxyapatite (HAp) on the surface of porous implants made of vinylidene fluoride and tetrafluoroethylene copolymer (P(VDF-TeFE)). This method consists of treating the surface of the product with a mixture of solvents while simultaneously capturing HAp microparticles. Using scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS), it was shown that the proposed method preserves the morphology of model implants (pore diameter and printed line thickness) and allows HAp to cover up to 63 ± 14% of their surface, reaching concentrations of calcium and phosphorus up to 6.0 ± 1.3 and 3.6 ± 0.7 at. %, respectively, imparting superhydrophilic properties to them. Optical profilometry revealed that the surface roughness of samples increased by more than seven times as a result of HAp immobilization. X-ray diffraction analysis (XRD) confirmed that the piezoelectric phase of P(VDF-TeFE) is preserved after treatment, as are the compressive strength characteristics of the samples. Hydroxyapatite immobilization significantly improved the adhesion and osteogenic differentiation of multipotent stem cells cultured with P(VDF-TeFE)-based samples. Thus, the proposed method can significantly enhance the biological activity of implants based on the piezoelectric VDF copolymer | ||
| 336 | |a Текстовый файл | ||
| 461 | 1 | |t Surfaces |c Basel |n MDPI AG | |
| 463 | 1 | |t Vol. 9, iss. 1 |v Article number 13, 15 p. |d 2026 | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a hydroxyapatite | |
| 610 | 1 | |a vinylidene fluoride | |
| 610 | 1 | |a surface modification | |
| 610 | 1 | |a bone implants | |
| 610 | 1 | |a cell adhesion | |
| 701 | 1 | |a Vorobjev |b A. O. |c Specialist in the field of material science |c Engineer of Tomsk Polytechnic University |f 1995- |g Aleksandr Olegovich |9 22645 | |
| 701 | 1 | |a Akimchenko |b I. O. |g Igor Olegovich | |
| 701 | 1 | |a Mukhametshin |b A. |g Anton | |
| 701 | 1 | |a Konoplyannikov |b M. A. |g Mikhail Anatoljevich | |
| 701 | 1 | |a Efremov |b Yu. M. | |
| 701 | 1 | |a Timashev |b P. S. | |
| 701 | 1 | |a Zvyagin |b A. V. |g Andrey Vasiljevich | |
| 701 | 1 | |a Bolbasov |b E. N. |c physicist |c Senior Researcher at Tomsk Polytechnic University, Candidate of Technical Sciences |f 1981- |g Evgeny Nikolaevich |9 15103 | |
| 701 | 1 | |a Goreninsky (Goreninskii) |b S. I. |c chemist |c engineer of Tomsk Polytechnic University |f 1993- |g Semen Igorevich |9 21234 | |
| 801 | 0 | |a RU |b 63413507 |c 20260512 | |
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| 856 | 4 | 0 | |u https://doi.org/10.3390/surfaces9010013 |z https://doi.org/10.3390/surfaces9010013 |
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