Long-term biocompatibility of fluoropolymer vascular grafts enhanced via magnetron-sputtered silicon-doped titanium nitride coatings; Colloids and Surfaces A: Physicochemical and Engineering Aspects; Vol. 735
| Parent link: | Colloids and Surfaces A: Physicochemical and Engineering Aspects.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 735.— 2026.— Article number 139480, 11 p. |
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| Այլ հեղինակներ: | , , , , , , , , , |
| Ամփոփում: | Title screen The clinical implementation of synthetic vascular grafts is severely limited by slow endothelialization, a challenge that is exacerbated by the chemical inertness of fluoropolymer materials such as poly(vinylidene fluoride-co-tetrafluoroethylene) (VDF-TeFE). To overcome this barrier, this study presents a biofunctionalization strategy for surfaces in which a thin coating of silicon-doped titanium nitride (TiSiN) is applied to electrospun VDF-TeFE blood vessel grafts using dual magnetron sputtering. This study systematically investigates the influence of coating deposition time (5 – 40 min) on the morphology, crystalline structure, surface chemistry, and in vitro biocompatibility of the VDF-TeFE grafts with human multipotent mesenchymal stem cells (MMSCs), assessed both direct after fabrication and after six months of storage. The coatings successfully enriched the surface with titanium, silicon, and nitrogen, with the nitrogen/silicon ratio being adjustable from 2.6 ± 0.3–1.7 ± 0.1. An optimal deposition time window of 5 – 10 min was established, minimizing fiber damage while maximizing cell adhesion and proliferation, as indicated by the highest cytoskeleton-to-nucleus area ratio. Crucially, this process preserved the ferroelectric β-phase of the copolymer used, which is essential for its piezoelectric "smart" functionality. The enhanced pro-adhesive bioactivity was maintained throughout the six-month long-term storage, confirming the stability of the coatings. This work establishes magnetron-sputtered TiSiN as a robust and durable surface engineering technique and advances the development of fluoropolymer-based grafts with high translational potential for rapid and stable endothelialization Текстовый файл AM_Agreement |
| Լեզու: | անգլերեն |
| Հրապարակվել է: |
2026
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| Խորագրեր: | |
| Առցանց հասանելիություն: | https://doi.org/10.1016/j.colsurfa.2026.139480 |
| Ձևաչափ: | Էլեկտրոնային Գրքի գլուխ |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=686186 |
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| 200 | 1 | |a Long-term biocompatibility of fluoropolymer vascular grafts enhanced via magnetron-sputtered silicon-doped titanium nitride coatings |f Semen I. Goreninskii, Dmitrii V. Sidelev, Sven Rutkowski [et al.] | |
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| 300 | |a Title screen | ||
| 320 | |a References: 64 tit | ||
| 330 | |a The clinical implementation of synthetic vascular grafts is severely limited by slow endothelialization, a challenge that is exacerbated by the chemical inertness of fluoropolymer materials such as poly(vinylidene fluoride-co-tetrafluoroethylene) (VDF-TeFE). To overcome this barrier, this study presents a biofunctionalization strategy for surfaces in which a thin coating of silicon-doped titanium nitride (TiSiN) is applied to electrospun VDF-TeFE blood vessel grafts using dual magnetron sputtering. This study systematically investigates the influence of coating deposition time (5 – 40 min) on the morphology, crystalline structure, surface chemistry, and in vitro biocompatibility of the VDF-TeFE grafts with human multipotent mesenchymal stem cells (MMSCs), assessed both direct after fabrication and after six months of storage. The coatings successfully enriched the surface with titanium, silicon, and nitrogen, with the nitrogen/silicon ratio being adjustable from 2.6 ± 0.3–1.7 ± 0.1. An optimal deposition time window of 5 – 10 min was established, minimizing fiber damage while maximizing cell adhesion and proliferation, as indicated by the highest cytoskeleton-to-nucleus area ratio. Crucially, this process preserved the ferroelectric β-phase of the copolymer used, which is essential for its piezoelectric "smart" functionality. The enhanced pro-adhesive bioactivity was maintained throughout the six-month long-term storage, confirming the stability of the coatings. This work establishes magnetron-sputtered TiSiN as a robust and durable surface engineering technique and advances the development of fluoropolymer-based grafts with high translational potential for rapid and stable endothelialization | ||
| 336 | |a Текстовый файл | ||
| 371 | 0 | |a AM_Agreement | |
| 461 | 1 | |t Colloids and Surfaces A: Physicochemical and Engineering Aspects |c Amsterdam |n Elsevier Science Publishing Company Inc. | |
| 463 | 1 | |t Vol. 735 |v Article number 139480, 11 p. |d 2026 | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a Artificial vessels | |
| 610 | 1 | |a Fluoropolymers | |
| 610 | 1 | |a Phosphor coating | |
| 610 | 1 | |a Si-doped TiN coatings | |
| 610 | 1 | |a Long-term storage | |
| 610 | 1 | |a Chemical stability | |
| 701 | 1 | |a Goreninsky (Goreninskii) |b S. I. |c chemist |c engineer of Tomsk Polytechnic University |f 1993- |g Semen Igorevich |9 21234 | |
| 701 | 1 | |a Sidelev |b D. V. |c physicist |c Associate Professor of Tomsk Polytechnic University, Candidate of Technical Sciences |f 1991- |g Dmitry Vladimirovich |9 17905 | |
| 701 | 1 | |a Rutkowski |b S. |c chemist |c Research Engineer, Tomsk Polytechnic University, Ph.D |f 1981- |g Sven |9 22409 | |
| 701 | 1 | |a Laushkina |b A. A. |g Alina Alekseevna | |
| 701 | 1 | |a Kukartseva |b O. V. |g Oksana Vasilievna |f 1984- |c physicist, environmental engineer |c Engineer of Tomsk Polytechnic University |9 89247 | |
| 701 | 1 | |a Fedotkin |b A. Yu. |c physicist |c engineer of Tomsk Polytechnic University |f 1994- |g Aleksandr Yurjevich |9 21763 | |
| 701 | 1 | |a Mishanin |b A. I. |g Aleksandr Igorevich | |
| 701 | 1 | |a Golovkin |b A. S. |g Aleksey Sergeevich | |
| 701 | 1 | |a Bolbasov |b E. N. |c physicist |c Senior Researcher at Tomsk Polytechnic University, Candidate of Technical Sciences |f 1981- |g Evgeny Nikolaevich |9 15103 | |
| 701 | 1 | |a Yaroslavtsev |b A. B. |g Andrey Borisovich | |
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