New Deep Eutectic Solvents Based on Urea and Amino Acids in Efficient Syntheses of N-Carbamoylamino Acids; Russian Journal of General Chemistry; Vol. 89 iss. 7

Dettagli Bibliografici
Parent link:Russian Journal of General Chemistry.— .— New York: Springer Science+Business Media LLC.
Vol. 89 iss. 7.— 2026.— Article number 7, 11 p.
Altri autori: Khovrenko E. V. Elena Vladislavovna, Shagzhaeva D. D. Dolgor Dorzhievna, Shtrykova V. V. Viktoriya Viktorovna, Bondarev A. A. Aleksandr Aleksandrovich, Filimonov V. D. Viktor Dmitrievich
Riassunto:Title screen
It is shown that the mixture of urea with certain ratios of KOH (in contrast to NaOH, LiOH, and other alkalis), forms liquid eutectic mixtures similar to deep eutectic solvents (DES), which rapidly react with L-amino acids, yielding chiral N-carbamoylamino acids with high yields. At the same time, amino acid esters and aromatic amines do not enter into this reaction. DFT methods were used to confirm the proposed mechanism of carbamoylation of amino acids in discovered conditions. Molecular dynamics and DFT methods were used to investigate the structure of the obtained DES and explain why only KOH, but not other alkalis, forms liquid eutectic mixtures with urea
Текстовый файл
AM_Agreement
Lingua:inglese
Pubblicazione: 2026
Soggetti:
Accesso online:https://doi.org/10.1134/S1070363225606295
Natura: Elettronico Capitolo di libro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=686067

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330 |a It is shown that the mixture of urea with certain ratios of KOH (in contrast to NaOH, LiOH, and other alkalis), forms liquid eutectic mixtures similar to deep eutectic solvents (DES), which rapidly react with L-amino acids, yielding chiral N-carbamoylamino acids with high yields. At the same time, amino acid esters and aromatic amines do not enter into this reaction. DFT methods were used to confirm the proposed mechanism of carbamoylation of amino acids in discovered conditions. Molecular dynamics and DFT methods were used to investigate the structure of the obtained DES and explain why only KOH, but not other alkalis, forms liquid eutectic mixtures with urea 
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