Immunogenic cell death-inducing Rh(i) and Ir(i) complexes with bis(imino)acenaphthene-derived ligands: insights into the role of the metal center and the ligands; Inorganic Chemistry Frontiers; Vol. 13, iss. 2

Immunogenic cell death-inducing Rh(i) and Ir(i) complexes with bis(imino)acenaphthene-derived ligands: insights into the role of the metal center and the ligands; Inorganic Chemistry Frontiers; Vol. 13, iss. 2

Bibliographic Details
Parent link:Inorganic Chemistry Frontiers.— .— London: Royal Society of Chemistry
Vol. 13, iss. 2.— 2026.— P. 403-419
Other Authors: Chengnan Wu, Romashev N. F. Nikolai, Komlyagina V. Veronika, Petrović T. Tamara, Bakaev I. V. Ivan, Abramov P. A. Pavel Aleksandrovich, Yuan Wang, Ryadun A. A. Alexey, Fomenko I. S. Iakov, Taotao Zou, Gushchin A. L. Artem, Babak M. V. Maria
Summary:Title screen
While various metal complexes demonstrate immunogenic cell death (ICD)-inducing properties, there is a lack of studies comparing ICD properties in structurally similar complexes with different metal centers. In this study, we synthesized four structurally similar Rh(I) and Ir(I) complexes with redox-active 1,2-bis(arylimino)acenaphthene (Ar-bian) ligands and assessed their anticancer and ICD-inducing properties. Analysis of damage-associated molecular patterns (DAMPs), ROS localization and dying cell populations highlighted the distinct roles of the metal center and the ligands. Specifically, only Rh(I) complexes induced the release of the three essential DAMPs and high levels of late apoptotic cells, while the Ir(I) complexes failed to trigger crucial “eat-me” signals. This work offers valuable insights into structure–activity relationships in metal complexes in the context of ICD
Текстовый файл
AM_Agreement
Language:English
Published: 2026
Subjects:
электронный ресурс
труды учёных ТПУ
Online Access:https://doi.org/10.1039/D5QI00868A
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=685896

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