Immunogenic cell death-inducing Rh(i) and Ir(i) complexes with bis(imino)acenaphthene-derived ligands: insights into the role of the metal center and the ligands; Inorganic Chemistry Frontiers; Vol. 13, iss. 2

Immunogenic cell death-inducing Rh(i) and Ir(i) complexes with bis(imino)acenaphthene-derived ligands: insights into the role of the metal center and the ligands; Inorganic Chemistry Frontiers; Vol. 13, iss. 2

Бібліографічні деталі
Parent link:	Inorganic Chemistry Frontiers.— .— London: Royal Society of Chemistry Vol. 13, iss. 2.— 2026.— P. 403-419
Інші автори:	Chengnan Wu, Romashev N. F. Nikolai, Komlyagina V. Veronika, Petrović T. Tamara, Bakaev I. V. Ivan, Abramov P. A. Pavel Aleksandrovich, Yuan Wang, Ryadun A. A. Alexey, Fomenko I. S. Iakov, Taotao Zou, Gushchin A. L. Artem, Babak M. V. Maria
Резюме:	Title screen While various metal complexes demonstrate immunogenic cell death (ICD)-inducing properties, there is a lack of studies comparing ICD properties in structurally similar complexes with different metal centers. In this study, we synthesized four structurally similar Rh(I) and Ir(I) complexes with redox-active 1,2-bis(arylimino)acenaphthene (Ar-bian) ligands and assessed their anticancer and ICD-inducing properties. Analysis of damage-associated molecular patterns (DAMPs), ROS localization and dying cell populations highlighted the distinct roles of the metal center and the ligands. Specifically, only Rh(I) complexes induced the release of the three essential DAMPs and high levels of late apoptotic cells, while the Ir(I) complexes failed to trigger crucial “eat-me” signals. This work offers valuable insights into structure–activity relationships in metal complexes in the context of ICD Текстовый файл AM_Agreement
Мова:	Англійська
Опубліковано:	2026
Предмети:	электронный ресурс труды учёных ТПУ
Онлайн доступ:	https://doi.org/10.1039/D5QI00868A
Формат:	Електронний ресурс Частина з книги
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=685896

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