Heat and mass transfer processes in drug aerosol flows in a human proximal respiratory tract; Journal of Aerosol Science; Vol. 193
| Parent link: | Journal of Aerosol Science.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 193.— 2026.— Article number 106757, 19 p. |
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| Autres auteurs: | , , , |
| Résumé: | Title screen A predictive three-dimensional mathematical model of aerosol dynamics and heat/mass transfer processes in a human proximal respiratory tract, based on Comsol Multiphysics 6.2, is described. In contrast to the previously developed models of these processes, the focus of the new model is on cases when air humidity in the respiratory tract is relatively low and aerosol evaporation is greater than hydroscopic growth. This case is important for several medical applications, including: hyperventilation following a known mechanism of exercise-induced bronchoconstriction; inhalation by patients of dry ambient air; and patient dehydration and respiratory diseases (bronchial asthma, chronic obstructive pulmonary disease (COPD), SARS). Aerosol evaporation is described by the Maxwell equation which is justified for small Spalding mass transfer numbers. The predictions of the model are validated using the experimental results available in the literature and in-house experimental data. It is pointed out that the effects of aerosol heating and evaporation on their dynamics cannot be ignored when modelling the process of drug delivery to patients’ respiratory tracts, especially for patients with high body temperatures. High human body temperature is shown to increase the predicted rate of aerosol evaporation leading to a decrease in their diameters. The latter affects the depth of penetration of aerosols into the proximal respiratory tract and their deposition within it. Most aerosols are expected to be deposited in the extrathoracic airways and least in the trachea. The location of bronchi is demonstrated to be asymmetric and this asymmetry is shown to lead to the asymmetry of aerosol deposition within them. The high accuracy of predicting the deposition of aerosols and their distribution along the respiratory tract, taking into account the contributions of heat and mass transfer processes, is shown to be important for the personalised selection of inhalation therapy parameters, which opens up prospects for improving the effectiveness of treatment strategies in respiratory medicine Текстовый файл AM_Agreement |
| Langue: | anglais |
| Publié: |
2026
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| Sujets: | |
| Accès en ligne: | https://doi.org/10.1016/j.jaerosci.2026.106757 |
| Format: | Électronique Chapitre de livre |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=685864 |
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| 200 | 1 | |a Heat and mass transfer processes in drug aerosol flows in a human proximal respiratory tract |f D. V. Antonov, O. V. Nagatkina, E. S. Ainetdinova, S. S. Sazhin | |
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| 330 | |a A predictive three-dimensional mathematical model of aerosol dynamics and heat/mass transfer processes in a human proximal respiratory tract, based on Comsol Multiphysics 6.2, is described. In contrast to the previously developed models of these processes, the focus of the new model is on cases when air humidity in the respiratory tract is relatively low and aerosol evaporation is greater than hydroscopic growth. This case is important for several medical applications, including: hyperventilation following a known mechanism of exercise-induced bronchoconstriction; inhalation by patients of dry ambient air; and patient dehydration and respiratory diseases (bronchial asthma, chronic obstructive pulmonary disease (COPD), SARS). Aerosol evaporation is described by the Maxwell equation which is justified for small Spalding mass transfer numbers. The predictions of the model are validated using the experimental results available in the literature and in-house experimental data. It is pointed out that the effects of aerosol heating and evaporation on their dynamics cannot be ignored when modelling the process of drug delivery to patients’ respiratory tracts, especially for patients with high body temperatures. High human body temperature is shown to increase the predicted rate of aerosol evaporation leading to a decrease in their diameters. The latter affects the depth of penetration of aerosols into the proximal respiratory tract and their deposition within it. Most aerosols are expected to be deposited in the extrathoracic airways and least in the trachea. The location of bronchi is demonstrated to be asymmetric and this asymmetry is shown to lead to the asymmetry of aerosol deposition within them. The high accuracy of predicting the deposition of aerosols and their distribution along the respiratory tract, taking into account the contributions of heat and mass transfer processes, is shown to be important for the personalised selection of inhalation therapy parameters, which opens up prospects for improving the effectiveness of treatment strategies in respiratory medicine | ||
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| 463 | 1 | |t Vol. 193 |v Article number 106757, 19 p. |d 2026 | |
| 610 | 1 | |a Aerosol | |
| 610 | 1 | |a Heat and mass transfer | |
| 610 | 1 | |a Three-dimensional modelling | |
| 610 | 1 | |a Drug deposition | |
| 610 | 1 | |a Respiratory tract | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Antonov |b D. V. |c specialist in the field of heat and power engineering |c Associate Professor, Research Engineer at Tomsk Polytechnic University, Candidate of Physical and Mathematical Sciences |f 1996- |g Dmitry Vladimirovich |9 22322 | |
| 701 | 1 | |a Nagatkina |b O. V. |g Olga Vladimirovna | |
| 701 | 1 | |a Aynetdinova |b E. S. |g Elizaveta Sergeevna | |
| 701 | 1 | |a Sazhin |b S. S. |c geophysicist |c Leading researcher at Tomsk Polytechnic University, PhD in Physics and Mathematics |f 1949- |g Sergey Stepanovich |9 88718 | |
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