A novel urea derivative anticonvulsant: In vivo biological evaluation, radioreceptor analysis of GABAA receptors and molecular docking studies of enantiomers; Mendeleev Communications; Vol. 33, iss. 4

A novel urea derivative anticonvulsant: In vivo biological evaluation, radioreceptor analysis of GABAA receptors and molecular docking studies of enantiomers; Mendeleev Communications; Vol. 33, iss. 4

書目詳細資料
Parent link:	Mendeleev Communications.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 33, iss. 4.— 2023.— P. 546-549
其他作者:	Shushpanova T. V. Tamara Vladimirovna, Bokhan N. A. Nikolay Aleksandrovich, Kuksenok V. Yu. Vera Yurievna, Shtrykova V. V. Viktoriya Viktorovna, Shushpanova O. V. Olga Vladimirovna, Udut V. V. Vladimir Vasiljevich
總結:	It has been experimentally established that the original new generation anticonvulsant Galodif, N-[(3-chlorophenyl)-(phenyl)methyl]urea, allosterically modulates GABAA receptor (GABAAR). Binding of [3H]flunitrazepam and [3H]Ro5-4864 to the benzodiazepine (BZD) site of GABAAR in the brain of Galodif-treated rats showes an increase in receptor affinity in Scatchard Plot for Ligand Receptor binding analysis. The results of molecular docking (Schrödinger program Glide) reveal that the enantiomers of Galodif are complementary to the BZD binding site of GABAAR; binding energy of R-Galodif is lower than that of S-Galodif (scoring GScore being –11.14 and –10.7 kcal mol–1, respectively); R-Galodif interacts with key amino acids at the α1γ2 interface: Tyr159, Tyr209, H101 Phe77 with high model fit – dG of insert: 7.41. Текстовый файл AM_Agreement
語言:	英语
出版:	2023
主題:	anticonvulsants γ-aminobutyric acid molecular docking GABAA receptor enantiomers электронный ресурс труды учёных ТПУ
在線閱讀:	https://doi.org/10.1016/j.mencom.2023.06.034
格式:	電子 Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=685514

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