Tailoring the topography, crystalline structure, and piezoelectric response of electrospun biodegradable poly(3-hydroxybutyrate) scaffolds by glycine loading; Advanced Composites and Hybrid Materials; Vol. 8, iss. 6
| Parent link: | Advanced Composites and Hybrid Materials.— .— Basel: Springer Nature Switzerland AG Vol. 8, iss. 6.— 2025.— Artcile number 424, 18 p. |
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| Outros autores: | , , , , , , , , , |
| Summary: | Title screen Tissue engineering (TE) represents an interdisciplinary field introduced for the recovery, preservation, and improvement of tissue function. Piezopolymers make it possible to generate exogenous potentials close to endogenous ones to promote tissue regeneration. Biodegradable poly(3-hydroxybutyrate) (PHB) has gained particular attention; however, the piezoelectric (PE) response of PHB is poor, and there is a need to improve it without compromising the biocompatibility of the scaffold. Herein, a drastic increase in the PE response of electrospun PHB scaffolds was achieved by incorporation of homogeneously distributed crystals of piezoactive β-glycine (Gly). We successfully optimized the electrospinning parameters to prepare composite PHB fibers with Gly content (5, 15, 20, and 30 wt%) and tailored topography, crystalline structure, and PE response. Gly incorporation creates a nanoporous textured surface of polymer fibers, which improves surface area, surface wettability, and the free surface energy of intrinsically hydrophobic scaffolds. In addition, Gly crystals act as nucleators for PHB crystallization, diminishing the polymer crystallite size and increasing its crystallinity degree from (39.9 ± 0.8) % for pure PHB to (45.8 ± 1.6) % for PHB-Gly-30. Using piezoelectric force microscopy, we obtained distributions of PE response along the fibers, uncovering a considerable increase in the lateral PE response for PHB scaffolds with 30 wt% Gly (from 0.28 ± 0.13 to 3.9 ± 1.0 pm/V) due to (i) the presence of PE β-Gly phase and (ii) higher PHB crystallinity. First-principles calculations revealed that the interaction of the Gly molecule with PHB surfaces occurred predominantly through hydrogen bonding and demonstrated a mechanism ranging from strong physisorption to weak chemisorption. This study opens new fundamental insights into straightforward one-stage engineering of biodegradable piezopolymer properties and offers a prospective scaffold for a wide range of TE applications. Similar content being viewed by other Текстовый файл AM_Agreement |
| Idioma: | inglés |
| Publicado: |
2025
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| Subjects: | |
| Acceso en liña: | https://doi.org/10.1007/s42114-025-01487-8 |
| Formato: | Electrónico Capítulo de libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=685430 |
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| 200 | 1 | |a Tailoring the topography, crystalline structure, and piezoelectric response of electrospun biodegradable poly(3-hydroxybutyrate) scaffolds by glycine loading |f L. E. Shlapakova, V. V. Shvartsman, B. N. Slautin [et al.] | |
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| 330 | |a Tissue engineering (TE) represents an interdisciplinary field introduced for the recovery, preservation, and improvement of tissue function. Piezopolymers make it possible to generate exogenous potentials close to endogenous ones to promote tissue regeneration. Biodegradable poly(3-hydroxybutyrate) (PHB) has gained particular attention; however, the piezoelectric (PE) response of PHB is poor, and there is a need to improve it without compromising the biocompatibility of the scaffold. Herein, a drastic increase in the PE response of electrospun PHB scaffolds was achieved by incorporation of homogeneously distributed crystals of piezoactive β-glycine (Gly). We successfully optimized the electrospinning parameters to prepare composite PHB fibers with Gly content (5, 15, 20, and 30 wt%) and tailored topography, crystalline structure, and PE response. Gly incorporation creates a nanoporous textured surface of polymer fibers, which improves surface area, surface wettability, and the free surface energy of intrinsically hydrophobic scaffolds. In addition, Gly crystals act as nucleators for PHB crystallization, diminishing the polymer crystallite size and increasing its crystallinity degree from (39.9 ± 0.8) % for pure PHB to (45.8 ± 1.6) % for PHB-Gly-30. Using piezoelectric force microscopy, we obtained distributions of PE response along the fibers, uncovering a considerable increase in the lateral PE response for PHB scaffolds with 30 wt% Gly (from 0.28 ± 0.13 to 3.9 ± 1.0 pm/V) due to (i) the presence of PE β-Gly phase and (ii) higher PHB crystallinity. First-principles calculations revealed that the interaction of the Gly molecule with PHB surfaces occurred predominantly through hydrogen bonding and demonstrated a mechanism ranging from strong physisorption to weak chemisorption. This study opens new fundamental insights into straightforward one-stage engineering of biodegradable piezopolymer properties and offers a prospective scaffold for a wide range of TE applications. Similar content being viewed by other | ||
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| 461 | 1 | |t Advanced Composites and Hybrid Materials |c Basel |n Springer Nature Switzerland AG | |
| 463 | 1 | |t Vol. 8, iss. 6 |v Artcile number 424, 18 p. |d 2025 | |
| 610 | 1 | |a Poly(3-hydroxybutyrate) | |
| 610 | 1 | |a Glycine | |
| 610 | 1 | |a Electrospinning | |
| 610 | 1 | |a Piezoelectricity | |
| 610 | 1 | |a Tissue engineering | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Shlapakova |b L. E. |c chemical engineer |c Research Engineer of Tomsk Polytechnic University |f 1999- |g Lada Evgenievna |9 88580 | |
| 701 | 1 | |a Shvartsman |b V. V. |g Vladimir | |
| 701 | 1 | |a Slautin |b B. N. |g Boris | |
| 701 | 1 | |a Lupascu |b D. C. |g Doru | |
| 701 | 1 | |a Grubova |b I. Yu. |c physicist |c engineer-researcher of Tomsk Polytechnic Universit |f 1989- |g Irina Yurievna |9 16573 | |
| 701 | 0 | |a Sun Yi-Yang | |
| 701 | 1 | |a Botvin |b V. V. |c chemist |c Senior Researcher of Tomsk Polytechnic University, Candidate of chemical sciences |f 1991- |g Vladimir Viktorovich |9 22791 | |
| 701 | 1 | |a Mathur |b S. |g Sanjay | |
| 701 | 1 | |a Surmenev |b R. A. |c physicist |c Associate Professor of Tomsk Polytechnic University, Senior researcher, Candidate of physical and mathematical sciences |f 1982- |g Roman Anatolievich |9 15957 | |
| 701 | 1 | |a Surmeneva |b M. A. |c specialist in the field of material science |c engineer-researcher of Tomsk Polytechnic University, Associate Scientist |f 1984- |g Maria Alexandrovna |9 15966 | |
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