Anisotropic nanorod-integrated magneto-mechano-electric cascade system for neural electrical stimulation
| Parent link: | Acta Biomaterialia.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 209.— 2026.— P. 452-465 |
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| Other Authors: | , , , , , , , , , , |
| Summary: | Title screen Piezoelectric materials are now being considered as a potential treatment system for neural electrical stimulation. However, their therapeutic efficacy is limited by insufficient electrical outputs, which are generated by cellular forces and/or tissue motions. Herein, we constructed a high-efficiency magneto-mechano-electric cascade system with magnetic field (MF)-driven wireless electrical stimulation. The anisotropic Fe3O4 nanorod (RFO)-integrated poly(vinylidene fluoride-co-trifluoroethylene) copolymer (PVDF-TrFE) fibrous scaffold (PT-RFO) with enhanced piezoelectric β-phase content was prepared via electrospinning technique. Under a remote pulsed MF, the high-efficiency electrical outputs within PT-RFO scaffold could be generated by converting pressure force and deflection force within the contact interface between anisotropic RFO and PVDF-TrFE matrix. As a result, such PT-RFO scaffold could accelerate the repair of injured sciatic nerves and promote the recovery of damaged motor functions in rat models. This work highlights the potential application of a wireless controllable cascade stimulation system integrated multiple designable cues for neural repair and modulation Текстовый файл AM_Agreement |
| Language: | English |
| Published: |
2026
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| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.actbio.2025.11.007 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=685366 |
| Summary: | Title screen Piezoelectric materials are now being considered as a potential treatment system for neural electrical stimulation. However, their therapeutic efficacy is limited by insufficient electrical outputs, which are generated by cellular forces and/or tissue motions. Herein, we constructed a high-efficiency magneto-mechano-electric cascade system with magnetic field (MF)-driven wireless electrical stimulation. The anisotropic Fe3O4 nanorod (RFO)-integrated poly(vinylidene fluoride-co-trifluoroethylene) copolymer (PVDF-TrFE) fibrous scaffold (PT-RFO) with enhanced piezoelectric β-phase content was prepared via electrospinning technique. Under a remote pulsed MF, the high-efficiency electrical outputs within PT-RFO scaffold could be generated by converting pressure force and deflection force within the contact interface between anisotropic RFO and PVDF-TrFE matrix. As a result, such PT-RFO scaffold could accelerate the repair of injured sciatic nerves and promote the recovery of damaged motor functions in rat models. This work highlights the potential application of a wireless controllable cascade stimulation system integrated multiple designable cues for neural repair and modulation Текстовый файл AM_Agreement |
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| DOI: | 10.1016/j.actbio.2025.11.007 |