Hydrodynamic elements of aerosol flows for targeted drug delivery into the respiratory tract; Journal of Aerosol Science; Vol. 193
| Parent link: | Journal of Aerosol Science.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 193.— 2026.— Article number 106762, 20 p. |
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| Altri autori: | , , , |
| Riassunto: | Title screen Aerosol inhalation is a widely used method for the safe and non-invasive drug delivery into the respiratory tract. However, pulmonary drug deposition typically remains below 60%. This low efficiency is mainly controlled by the non-stable aerosol flow characteristics from the delivery device to the oropharynx, including aerosol radii and velocity distributions. In this study, the hydrodynamic behavior of aerosol flows was investigated using optical diagnostic techniques, including Phase Doppler Anemometry, shadow photography, and tracer visualization. Three inhalation drug delivery systems were examined: a pressurized metered-dose inhaler (pMDI), a jet nebulizer with constant flow rate, and a soft mist inhaler (Respimat®). Unsteady velocity fields of the liquid aerosol were recorded. Both large- and small-scale flow structures were identified as the aerosol exited the device at various angles and impacted a model hydrophilic barrier. Quantitative results are provided in both dimensional and dimensionless forms, including graphical relationships and fitted expressions to support future mathematical modeling Текстовый файл AM_Agreement |
| Lingua: | inglese |
| Pubblicazione: |
2026
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| Soggetti: | |
| Accesso online: | https://doi.org/10.1016/j.jaerosci.2026.106762 |
| Natura: | Elettronico Capitolo di libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=685158 |
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| 200 | 1 | |a Hydrodynamic elements of aerosol flows for targeted drug delivery into the respiratory tract |f D. V. Antonov, S. A. Kerimbekova, O. V. Nagatkina, O. A. Suvorova | |
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| 330 | |a Aerosol inhalation is a widely used method for the safe and non-invasive drug delivery into the respiratory tract. However, pulmonary drug deposition typically remains below 60%. This low efficiency is mainly controlled by the non-stable aerosol flow characteristics from the delivery device to the oropharynx, including aerosol radii and velocity distributions. In this study, the hydrodynamic behavior of aerosol flows was investigated using optical diagnostic techniques, including Phase Doppler Anemometry, shadow photography, and tracer visualization. Three inhalation drug delivery systems were examined: a pressurized metered-dose inhaler (pMDI), a jet nebulizer with constant flow rate, and a soft mist inhaler (Respimat®). Unsteady velocity fields of the liquid aerosol were recorded. Both large- and small-scale flow structures were identified as the aerosol exited the device at various angles and impacted a model hydrophilic barrier. Quantitative results are provided in both dimensional and dimensionless forms, including graphical relationships and fitted expressions to support future mathematical modeling | ||
| 336 | |a Текстовый файл | ||
| 371 | 0 | |a AM_Agreement | |
| 461 | 1 | |t Journal of Aerosol Science |c Amsterdam |n Elsevier Science Publishing Company Inc. | |
| 463 | 1 | |t Vol. 193 |v Article number 106762, 20 p. |d 2026 | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a Inhalation aerosol | |
| 610 | 1 | |a Targeted drug delivery | |
| 610 | 1 | |a Experiment | |
| 610 | 1 | |a Optical diagnostic methods | |
| 610 | 1 | |a Phase Doppler anemometry | |
| 610 | 1 | |a Tracer visualization | |
| 610 | 1 | |a Shadow photography | |
| 701 | 1 | |a Antonov |b D. V. |c specialist in the field of heat and power engineering |c Associate Professor, Research Engineer at Tomsk Polytechnic University, Candidate of Physical and Mathematical Sciences |f 1996- |g Dmitry Vladimirovich |9 22322 | |
| 701 | 1 | |a Kerimbekova |b S. A. |c specialist in the field of heat and power engineering |c Engineer of Tomsk Polytechnic University |f 1991- |g Susanna Aleksandrovna |9 22816 | |
| 701 | 1 | |a Nagatkina |b O. V. |g Olga Vladimirovna | |
| 701 | 1 | |a Suvorova |b O. A. |g Olga Aleksandrovna | |
| 801 | 0 | |a RU |b 63413507 |c 20260225 | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jaerosci.2026.106762 |z https://doi.org/10.1016/j.jaerosci.2026.106762 |
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