Hydrodynamic elements of aerosol flows for targeted drug delivery into the respiratory tract
| Parent link: | Journal of Aerosol Science.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 193.— 2026.— Article number 106762, 20 p. |
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| Diğer Yazarlar: | , , , |
| Özet: | Title screen Aerosol inhalation is a widely used method for the safe and non-invasive drug delivery into the respiratory tract. However, pulmonary drug deposition typically remains below 60%. This low efficiency is mainly controlled by the non-stable aerosol flow characteristics from the delivery device to the oropharynx, including aerosol radii and velocity distributions. In this study, the hydrodynamic behavior of aerosol flows was investigated using optical diagnostic techniques, including Phase Doppler Anemometry, shadow photography, and tracer visualization. Three inhalation drug delivery systems were examined: a pressurized metered-dose inhaler (pMDI), a jet nebulizer with constant flow rate, and a soft mist inhaler (Respimat®). Unsteady velocity fields of the liquid aerosol were recorded. Both large- and small-scale flow structures were identified as the aerosol exited the device at various angles and impacted a model hydrophilic barrier. Quantitative results are provided in both dimensional and dimensionless forms, including graphical relationships and fitted expressions to support future mathematical modeling Текстовый файл AM_Agreement |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
2026
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| Konular: | |
| Online Erişim: | https://doi.org/10.1016/j.jaerosci.2026.106762 |
| Materyal Türü: | Elektronik Kitap Bölümü |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=685158 |
| Özet: | Title screen Aerosol inhalation is a widely used method for the safe and non-invasive drug delivery into the respiratory tract. However, pulmonary drug deposition typically remains below 60%. This low efficiency is mainly controlled by the non-stable aerosol flow characteristics from the delivery device to the oropharynx, including aerosol radii and velocity distributions. In this study, the hydrodynamic behavior of aerosol flows was investigated using optical diagnostic techniques, including Phase Doppler Anemometry, shadow photography, and tracer visualization. Three inhalation drug delivery systems were examined: a pressurized metered-dose inhaler (pMDI), a jet nebulizer with constant flow rate, and a soft mist inhaler (Respimat®). Unsteady velocity fields of the liquid aerosol were recorded. Both large- and small-scale flow structures were identified as the aerosol exited the device at various angles and impacted a model hydrophilic barrier. Quantitative results are provided in both dimensional and dimensionless forms, including graphical relationships and fitted expressions to support future mathematical modeling Текстовый файл AM_Agreement |
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| DOI: | 10.1016/j.jaerosci.2026.106762 |