Hydrolysis of Bone-Replacing Materials Based on Polylactic Acid and Containing Hydroxyapatite in an In Vitro Experiment; Bulletin of Experimental Biology and Medicine; Vol. 174, iss. 1
| Parent link: | Bulletin of Experimental Biology and Medicine.— .— New York: Springer Science+Business Media LLC. Vol. 174, iss. 1.— 2022.— P. 99–103 |
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| Další autoři: | , , , , , , , , , |
| Shrnutí: | Title screen We studied the features of hydrolytic degradation of polylactic acid (PLLA) implants depending on their structural filling with hydroxyapatite (HA). The resistance to in vitro hydrolysis was tested for the following samples: PLLA without HA (control; group 1), PLLA/HA 25 wt% (group 2), and PLLA/HA 50 wt% (group 3). Samples were incubated at 37°C. In the hydrolysate, lactate, calcium ions, and inorganic phosphate were determined. Additionally, the time of appearance of visual deformation and sample disintegration was recorded. PLLA degradation was higher in samples saturated with HA. The highest resistance to deformation was noted for samples without HA. Samples with a PLLA/HA 50 wt% demonstrated the maximum degradation of PLLA in combination with lower resistance to deformation and the highest bioavailability of calcium and phosphate. Group 2 samples are most promising for clinical use Текстовый файл AM_Agreement |
| Jazyk: | angličtina |
| Vydáno: |
2022
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| Témata: | |
| On-line přístup: | https://doi.org/10.1007/s10517-022-05656-3 |
| Médium: | Elektronický zdroj Kapitola |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=684990 |
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| 200 | 1 | |a Hydrolysis of Bone-Replacing Materials Based on Polylactic Acid and Containing Hydroxyapatite in an In Vitro Experiment |f A. V. Popkov, M. V. Stogov, E. N. Gorbach [et al.] | |
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| 330 | |a We studied the features of hydrolytic degradation of polylactic acid (PLLA) implants depending on their structural filling with hydroxyapatite (HA). The resistance to in vitro hydrolysis was tested for the following samples: PLLA without HA (control; group 1), PLLA/HA 25 wt% (group 2), and PLLA/HA 50 wt% (group 3). Samples were incubated at 37°C. In the hydrolysate, lactate, calcium ions, and inorganic phosphate were determined. Additionally, the time of appearance of visual deformation and sample disintegration was recorded. PLLA degradation was higher in samples saturated with HA. The highest resistance to deformation was noted for samples without HA. Samples with a PLLA/HA 50 wt% demonstrated the maximum degradation of PLLA in combination with lower resistance to deformation and the highest bioavailability of calcium and phosphate. Group 2 samples are most promising for clinical use | ||
| 336 | |a Текстовый файл | ||
| 371 | 0 | |a AM_Agreement | |
| 461 | 1 | |t Bulletin of Experimental Biology and Medicine |c New York |n Springer Science+Business Media LLC. | |
| 463 | 1 | |t Vol. 174, iss. 1 |v P. 99–103 |d 2022 | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a implant | |
| 610 | 1 | |a polylactic acid (PLLA) | |
| 610 | 1 | |a hydroxyapatite (HA) | |
| 610 | 1 | |a hydrolytic degradation | |
| 701 | 1 | |a Popkov |b A. V. |g Arnold Vasiljevich | |
| 701 | 1 | |a Stogov |b M. V. |g Maksim Valerjevich | |
| 701 | 1 | |a Gorbach |b E. N. |g Elena Nikolaevna | |
| 701 | 1 | |a Kononovich |b N. A. |c Nataljya Andreevna | |
| 701 | 1 | |a Tushina |b N. V. |g Nataljya Vladimirovna | |
| 701 | 1 | |a Tverdokhlebov |b S. I. |c physicist |c Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science |f 1961- |g Sergei Ivanovich |9 15101 | |
| 701 | 1 | |a Dubinenko |b G. E. |c Specialist in the field of material science |c Engineer of Tomsk Polytechnic University |f 1992- |g Gleb Evgenjevich |9 21551 | |
| 701 | 1 | |a Akimchenko |b I. O. |c Physicist |c Engineer of Tomsk Polytechnic University |f 1996- |g Igor Olegovich |9 22643 | |
| 701 | 1 | |a Bolbasov |b E. N. |c physicist |c Senior Researcher at Tomsk Polytechnic University, Candidate of Technical Sciences |f 1981- |g Evgeny Nikolaevich |9 15103 | |
| 701 | 1 | |a Popkov |b D. A. |g Dmitry Arnoldovich | |
| 801 | 0 | |a RU |b 63413507 |c 20260218 | |
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