The Specifics of Neovascularization of Wound Defects in the Oral Mucosa during Its Regeneration under a Piezoelectric Polymer Membrane; Bulletin of Experimental Biology and Medicine; Vol. 174, iss. 6

The Specifics of Neovascularization of Wound Defects in the Oral Mucosa during Its Regeneration under a Piezoelectric Polymer Membrane; Bulletin of Experimental Biology and Medicine; Vol. 174, iss. 6

Détails bibliographiques
Parent link:Bulletin of Experimental Biology and Medicine.— .— New York: Springer Science+Business Media LLC.
Vol. 174, iss. 6.— 2023.— P. 801–805
Autres auteurs: Koniaeva A. D. Anastasiya Denisovna, Varakuta E. Yu. Elena Yurjevna, Leyman A. E. Arina Evgenjevna, Bolbasov E. N. Evgeny Nikolaevich, Chernova Y. V. Ulyana Vadimovna
Résumé:Title screen
We studied restoration of microvessels in the oral mucosa wound defects under a polymer piezoelectric membrane (group 2) and without it (group 1). The control group included animals with intact mucosa. On day 3, the expression of the vascular endothelial growth factor (VEGF) increased in all experimental groups, while the expression of CD34 increased only in group 2, which attested to intensive neoangiogenesis. On day 7, we observed a decrease in VEGF expression and an increase in CD34 expression that was more pronounced in group 2, which reflected the beginning of blood vessels maturation. More rapid formation and maturation of blood vessels in group 2 was confirmed by electron microscopy: on day 7, endothelial cells with mature organelles and signs of active transcapillary exchange were seen. On day 12, the immature blood vessels still predominated in group 1, while in group 2, the expression of angiogenesis markers decreased though remained above the control, which created prerequisites for the complete restoration of wound area vascularization in group 2. In group 1, the expression of VEGF and CD34 was significantly below the control, which attested to the development of poorly vascularized scar tissue
Текстовый файл
AM_Agreement
Langue:anglais
Publié: 2023
Sujets:
электронный ресурс
труды учёных ТПУ
oral mucosa
neoangiogenesis
piezoelectric materials
regeneration
wound defect
Accès en ligne:https://doi.org/10.1007/s10517-023-05793-3
Format: Électronique Chapitre de livre
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=684988

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