The Specifics of Neovascularization of Wound Defects in the Oral Mucosa during Its Regeneration under a Piezoelectric Polymer Membrane; Bulletin of Experimental Biology and Medicine; Vol. 174, iss. 6
| Parent link: | Bulletin of Experimental Biology and Medicine.— .— New York: Springer Science+Business Media LLC. Vol. 174, iss. 6.— 2023.— P. 801–805 |
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| مؤلفون آخرون: | , , , , |
| الملخص: | Title screen We studied restoration of microvessels in the oral mucosa wound defects under a polymer piezoelectric membrane (group 2) and without it (group 1). The control group included animals with intact mucosa. On day 3, the expression of the vascular endothelial growth factor (VEGF) increased in all experimental groups, while the expression of CD34 increased only in group 2, which attested to intensive neoangiogenesis. On day 7, we observed a decrease in VEGF expression and an increase in CD34 expression that was more pronounced in group 2, which reflected the beginning of blood vessels maturation. More rapid formation and maturation of blood vessels in group 2 was confirmed by electron microscopy: on day 7, endothelial cells with mature organelles and signs of active transcapillary exchange were seen. On day 12, the immature blood vessels still predominated in group 1, while in group 2, the expression of angiogenesis markers decreased though remained above the control, which created prerequisites for the complete restoration of wound area vascularization in group 2. In group 1, the expression of VEGF and CD34 was significantly below the control, which attested to the development of poorly vascularized scar tissue Текстовый файл AM_Agreement |
| اللغة: | الإنجليزية |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.1007/s10517-023-05793-3 |
| التنسيق: | الكتروني فصل الكتاب |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=684988 |
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| 200 | 1 | |a The Specifics of Neovascularization of Wound Defects in the Oral Mucosa during Its Regeneration under a Piezoelectric Polymer Membrane |f A. D. Konyaeva, E. Yu. Varakuta, A. E. Leiman [et al.] | |
| 203 | |a Текст |b визуальный |c электронный | ||
| 283 | |a online_resource |2 RDAcarrier | ||
| 300 | |a Title screen | ||
| 320 | |a References: 13 tit | ||
| 330 | |a We studied restoration of microvessels in the oral mucosa wound defects under a polymer piezoelectric membrane (group 2) and without it (group 1). The control group included animals with intact mucosa. On day 3, the expression of the vascular endothelial growth factor (VEGF) increased in all experimental groups, while the expression of CD34 increased only in group 2, which attested to intensive neoangiogenesis. On day 7, we observed a decrease in VEGF expression and an increase in CD34 expression that was more pronounced in group 2, which reflected the beginning of blood vessels maturation. More rapid formation and maturation of blood vessels in group 2 was confirmed by electron microscopy: on day 7, endothelial cells with mature organelles and signs of active transcapillary exchange were seen. On day 12, the immature blood vessels still predominated in group 1, while in group 2, the expression of angiogenesis markers decreased though remained above the control, which created prerequisites for the complete restoration of wound area vascularization in group 2. In group 1, the expression of VEGF and CD34 was significantly below the control, which attested to the development of poorly vascularized scar tissue | ||
| 336 | |a Текстовый файл | ||
| 371 | 0 | |a AM_Agreement | |
| 461 | 1 | |t Bulletin of Experimental Biology and Medicine |c New York |n Springer Science+Business Media LLC. | |
| 463 | 1 | |t Vol. 174, iss. 6 |v P. 801–805 |d 2023 | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a oral mucosa | |
| 610 | 1 | |a neoangiogenesis | |
| 610 | 1 | |a piezoelectric materials | |
| 610 | 1 | |a regeneration | |
| 610 | 1 | |a wound defect | |
| 701 | 1 | |a Koniaeva |b A. D. |g Anastasiya Denisovna | |
| 701 | 1 | |a Varakuta |b E. Yu. |g Elena Yurjevna | |
| 701 | 1 | |a Leyman |b A. E. |g Arina Evgenjevna | |
| 701 | 1 | |a Bolbasov |b E. N. |c physicist |c Senior Researcher at Tomsk Polytechnic University, Candidate of Technical Sciences |f 1981- |g Evgeny Nikolaevich |9 15103 | |
| 701 | 1 | |a Chernova |b Y. V. |c chemist |c Engineer of Tomsk Polytechnic University |f 1997- |g Ulyana Vadimovna |9 88694 | |
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