Synthesis, Structure and Antiradical Activity of Functionally Substituted Hydrazides of Isonicotinic Acid
| Parent link: | Eurasian Chemico-Technological Journal.— .— Almaty: al-Farabi KazNU Vol. 25, No. 2.— 2023.— P. 121-128 |
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| مؤلفون آخرون: | , , , , , , , |
| الملخص: | Title screen The purpose of this work is the synthesis of new isonicotinic acid hydrazones, the study of their structure, reactivity and biological screening of some synthesized compounds. The reactions leading to new N-arylidene(alkylidene) hydrazones via the condensation of isonicotinic acid hydrazide with various derivatives of aromatic aldehydes were studied. The structure of the new functionally substituted isonicotinic acid hydrazones was established by FTIR, 1H and 13C NMR, two-dimensional COSY (1H-1H) NMR spectroscopy and HMQC (1H-13C). The antiradical activity of the synthesized derivatives was studied using diphenylpycrylhydrazide radical (DPPH) assay. It was shown that N-(3- ethoxy-4-hydroxybenzylidene)isonicotinohydrazide possesses antiradical activity (IC50 (DPPH) 103.0 μM). The antiradical properties of compounds of phenolic nature are in agreement with the energies of homolytic O-H bond dissociation calculated with the use of density functional theory Текстовый файл |
| اللغة: | الإنجليزية |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.18321/ectj1502 |
| التنسيق: | الكتروني فصل الكتاب |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=684729 |
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| 200 | 1 | |a Synthesis, Structure and Antiradical Activity of Functionally Substituted Hydrazides of Isonicotinic Acid |f O. Nurkenov, S. Fazylov, Z. Shulgau [et al.] | |
| 203 | |a Текст |c электронный |b визуальный | ||
| 283 | |a online_resource |2 RDAcarrier | ||
| 300 | |a Title screen | ||
| 320 | |a References: 16 tit | ||
| 330 | |a The purpose of this work is the synthesis of new isonicotinic acid hydrazones, the study of their structure, reactivity and biological screening of some synthesized compounds. The reactions leading to new N-arylidene(alkylidene) hydrazones via the condensation of isonicotinic acid hydrazide with various derivatives of aromatic aldehydes were studied. The structure of the new functionally substituted isonicotinic acid hydrazones was established by FTIR, 1H and 13C NMR, two-dimensional COSY (1H-1H) NMR spectroscopy and HMQC (1H-13C). The antiradical activity of the synthesized derivatives was studied using diphenylpycrylhydrazide radical (DPPH) assay. It was shown that N-(3- ethoxy-4-hydroxybenzylidene)isonicotinohydrazide possesses antiradical activity (IC50 (DPPH) 103.0 μM). The antiradical properties of compounds of phenolic nature are in agreement with the energies of homolytic O-H bond dissociation calculated with the use of density functional theory | ||
| 336 | |a Текстовый файл | ||
| 461 | 1 | |t Eurasian Chemico-Technological Journal |c Almaty |n al-Farabi KazNU | |
| 463 | 1 | |t Vol. 25, No. 2 |v P. 121-128 |d 2023 | |
| 610 | 1 | |a Isoniazid | |
| 610 | 1 | |a Aromatic aldehydes | |
| 610 | 1 | |a Two-dimensional spectra | |
| 610 | 1 | |a 1H and 13C NMR | |
| 610 | 1 | |a X-ray diffraction | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Nurkenov |b O. A. |g Oralgazy Aktaevich | |
| 701 | 1 | |a Fazylov |b S. D. |g Serik Drakhmetovich | |
| 701 | 1 | |a Shulgau |b Z. T. |g Zarina Toktamysovna | |
| 701 | 1 | |a Аbdrasilov |b B. S. |g Bolatbek Serikbaevich | |
| 701 | 1 | |a Khlebnikov |b A. I. |c Chemist |c Professor of Tomsk Polytechnic University |f 1963- |g Andrey Ivanovich |9 17500 | |
| 701 | 1 | |a Seylkhanov |b T. M. |g Tulegen Muratovich | |
| 701 | 1 | |a Kabieva |b S. K. |g Saule Kazzhanovna | |
| 701 | 1 | |a Karipova |b G. Zh. |g Gulzhanat Zhumazhanovna | |
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