Preparation of a nanodiamond suspension with immobilized lutetium-177 and study of its biodistribution; Journal of Radioanalytical and Nuclear Chemistry; Vol. 334, iss. 9
| Parent link: | Journal of Radioanalytical and Nuclear Chemistry.— .— New York: Springer Science+Business Media LLC. Vol. 334, iss. 9.— 2025.— P. 6029-6041 |
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| Other Authors: | , , , , , , , , , , |
| Summary: | Nanodiamonds (ND) were studied as nanosized carriers of medical isotope 177Lu. Conditions for preparation of a ND suspension with immobilized 177Lu in solutions which meet the requirements for intravenous administration of radiopharmaceuticals based on medical isotope 177Lu were determined. The possibility of quantitative bonding of lutetium with ND in isotonic solutions which have necessary pH and minimal amount of ND was demonstrated. The parameters of Freundlich and Langmuir adsorption isotherms and thermodynamic parameters of adsorption in optimal conditions for the most promising sample of ND were calculated. In vivo experiments for determination of biodistribution of 177Lu labeled ND in CD1 mice 4 and 48 h after intravenous injection were conducted. The highest percentage of isotope accumulation was observed in liver and spleen, and these values did not significantly decrease after 48 h; the increased accumulation in bone tissue was also detected. It was noted that 177Lu sorbed onto ND can be promisingly injected directly into tumor for therapy Текстовый файл AM_Agreement |
| Language: | English |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://doi.org/10.1007/s10967-025-10326-5 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=684386 |
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| 200 | 1 | |a Preparation of a nanodiamond suspension with immobilized lutetium-177 and study of its biodistribution |f Andrey G. Kazakov, Daria V. Pavlova, Taisia Y. Ekatova [et al.] | |
| 203 | |a Текст |b визуальный |c электронный | ||
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| 330 | |a Nanodiamonds (ND) were studied as nanosized carriers of medical isotope 177Lu. Conditions for preparation of a ND suspension with immobilized 177Lu in solutions which meet the requirements for intravenous administration of radiopharmaceuticals based on medical isotope 177Lu were determined. The possibility of quantitative bonding of lutetium with ND in isotonic solutions which have necessary pH and minimal amount of ND was demonstrated. The parameters of Freundlich and Langmuir adsorption isotherms and thermodynamic parameters of adsorption in optimal conditions for the most promising sample of ND were calculated. In vivo experiments for determination of biodistribution of 177Lu labeled ND in CD1 mice 4 and 48 h after intravenous injection were conducted. The highest percentage of isotope accumulation was observed in liver and spleen, and these values did not significantly decrease after 48 h; the increased accumulation in bone tissue was also detected. It was noted that 177Lu sorbed onto ND can be promisingly injected directly into tumor for therapy | ||
| 336 | |a Текстовый файл | ||
| 371 | 0 | |a AM_Agreement | |
| 461 | 1 | |t Journal of Radioanalytical and Nuclear Chemistry |c New York |n Springer Science+Business Media LLC. | |
| 463 | 1 | |t Vol. 334, iss. 9 |v P. 6029-6041 |d 2025 | |
| 610 | 1 | |a Nanodiamonds | |
| 610 | 1 | |a Sorption | |
| 610 | 1 | |a Adsorption isotherms | |
| 610 | 1 | |a In vivo experiments | |
| 610 | 1 | |a Nuclear medicine | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a электронный ресурс | |
| 701 | 1 | |a Kazakov |b A. G. |g Andrey | |
| 701 | 1 | |a Pavlova |b D. V. |g Daria | |
| 701 | 1 | |a Ekatova |b T. Y. |g Taisia | |
| 701 | 1 | |a Larkina |b M. S. |g Mariya Sergeevna |f 1984- |c pharmacist |c Professor; Senior Researcher of the Tomsk Polytechnic University, Doctor of Pharmaceutical Sciences |9 22417 | |
| 701 | 1 | |a Varvashenya |b R. N. |c pharmacist |c engineer at Tomsk Polytechnic University |f 1997- |g Ruslan Nikolaevich |9 88559 | |
| 701 | 1 | |a Yanovich |b G. |c Pharmacist |c engineer of Tomsk Polytechnic University |f 1999- |g Gleb |9 89205 | |
| 701 | 1 | |a Plotnikov |b E. V. |c chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences |f 1983- |g Evgeny Vladimirovich |9 16417 | |
| 701 | 1 | |a Ushakov |b I. A. |c physicist |c engineer at Tomsk Polytechnic University |f 1991- |g Ivan Alekseevich |9 18726 | |
| 701 | 1 | |a Nesterov |b E. A. |c Physicist, Specialist in the field of nuclear power engineering |c Researcher of Tomsk Polytechnic University |f 1976- |g Evgeny Alexandrovich |9 16556 | |
| 701 | 1 | |a Zukau |b V. V. |c physicist |c engineer of Tomsk Polytechnic University |f 1983- |g Valery Viktorovich |9 17779 | |
| 701 | 1 | |a Vinokurov |b S. E. |g Sergey | |
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