Mathematical model of nanodosing of water–thyme extract using droplet microfluidics; Physics of Fluids; Vol. 38. iss. 1
| Parent link: | Physics of Fluids.— .— New York: AIP Publishing Vol. 38. iss. 1.— 2026.— Article number 012005, 17 p. |
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| Інші автори: | , , , , , |
| Резюме: | Title screen The experimental study deals with the formation of multicomponent microdroplets with a size of 110–210 μm in a double-emulsion flow-focusing microfluidic chip by the squeezing mechanism during the interaction of three liquids. They include aqueous solutions of sodium alginate (shell) and beef gelatin with the addition of common thyme extract (core), as well as sunflower oil. A physical and mathematical energy and mass conservation-based model was developed to predict the diameter of a multicomponent liquid microdroplet, Dd. As a result of modeling, the factors defining Dd were explored, on the basis of which an empirical model rose from the capillary number for the oil phase (Cao 0.05–0.15) was proposed and verified. Empirical modeling of nanodosing characteristics revealed the multiscale influence of the flow rates of the three liquids involved and the concentrations of sodium alginate and thyme extract. The practical significance of the modeling is reflected by the correlation of the values of Dd with the nanodoses of biologically active substances with complex pharmacological effects, which were calculated using high-performance liquid chromatography of thyme extract. The feasibility of encapsulating aqueous thyme extract to create biologically active microsystems was confirmed Текстовый файл AM_Agreement |
| Мова: | Англійська |
| Опубліковано: |
2026
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| Предмети: | |
| Онлайн доступ: | https://doi.org/10.1063/5.0303637 |
| Формат: | Електронний ресурс Частина з книги |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=684368 |