Ascorbate induces G2/M arrest and necrosis without generation of direct DNA double-strand breaks; Heliyon; Vol. 11

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Parent link:	Heliyon.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 11.— 2025.— Article number e43964, 14 p.
Outros Autores:	Hariri M. Mehran, Papalanis E. Eleftherios, Spiegelberg D. Diana, Plotnikov E. V. Evgeny Vladimirovich, Viktorsson K. Kristina, Stenerlow B. Bo
Resumo:	Title screen Ascorbate is used for combination therapy with promising results in clinical trials. The proposed main ascorbate cytotoxic effect is DNA damage induction through excessive oxidative stress. However, the involvement of DNA double-strand breakage (DSB) formation and repair in ascorbate-induced DNA damage remains to be revealed Текстовый файл AM_Agreement
Idioma:	inglês
Publicado em:	2025
Assuntos:	Ascorbate DSB NHEJ γH2AX 53BP1 XRCC4 DNA-PKcs cell cycle электронный ресурс труды учёных ТПУ
Acesso em linha:	https://doi.org/10.1016/j.heliyon.2025.e43964
Formato:	Recurso Electrónico Capítulo de Livro
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=683007

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