Ascorbate induces G2/M arrest and necrosis without generation of direct DNA double-strand breaks; Heliyon; Vol. 11
| Parent link: | Heliyon.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 11.— 2025.— Article number e43964, 14 p. |
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| Altri autori: | , , , , , |
| Riassunto: | Title screen Ascorbate is used for combination therapy with promising results in clinical trials. The proposed main ascorbate cytotoxic effect is DNA damage induction through excessive oxidative stress. However, the involvement of DNA double-strand breakage (DSB) formation and repair in ascorbate-induced DNA damage remains to be revealed Текстовый файл AM_Agreement |
| Lingua: | inglese |
| Pubblicazione: |
2025
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| Soggetti: | |
| Accesso online: | https://doi.org/10.1016/j.heliyon.2025.e43964 |
| Natura: | MixedMaterials Elettronico Capitolo di libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=683007 |
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| 330 | |a Ascorbate is used for combination therapy with promising results in clinical trials. The proposed main ascorbate cytotoxic effect is DNA damage induction through excessive oxidative stress. However, the involvement of DNA double-strand breakage (DSB) formation and repair in ascorbate-induced DNA damage remains to be revealed | ||
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