Ascorbate induces G2/M arrest and necrosis without generation of direct DNA double-strand breaks; Heliyon; Vol. 11

Bibliografiske detaljer
Parent link:	Heliyon.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 11.— 2025.— Article number e43964, 14 p.
Andre forfattere:	Hariri M. Mehran, Papalanis E. Eleftherios, Spiegelberg D. Diana, Plotnikov E. V. Evgeny Vladimirovich, Viktorsson K. Kristina, Stenerlow B. Bo
Summary:	Title screen Ascorbate is used for combination therapy with promising results in clinical trials. The proposed main ascorbate cytotoxic effect is DNA damage induction through excessive oxidative stress. However, the involvement of DNA double-strand breakage (DSB) formation and repair in ascorbate-induced DNA damage remains to be revealed Текстовый файл AM_Agreement
Sprog:	engelsk
Udgivet:	2025
Fag:	Ascorbate DSB NHEJ γH2AX 53BP1 XRCC4 DNA-PKcs cell cycle электронный ресурс труды учёных ТПУ
Online adgang:	https://doi.org/10.1016/j.heliyon.2025.e43964
Format:	Electronisk Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=683007

Beskrivelse
Summary:	Title screen Ascorbate is used for combination therapy with promising results in clinical trials. The proposed main ascorbate cytotoxic effect is DNA damage induction through excessive oxidative stress. However, the involvement of DNA double-strand breakage (DSB) formation and repair in ascorbate-induced DNA damage remains to be revealed Текстовый файл AM_Agreement
DOI:	10.1016/j.heliyon.2025.e43964

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