Конъюгат на основе инвертазы для оценки качества вакцин с помощью персонального глюкометра

Конъюгат на основе инвертазы для оценки качества вакцин с помощью персонального глюкометра

Bibliographic Details
Parent link:Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XХII Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 22-25 апреля 2025/ Национальный исследовательский Томский политехнический университет ; под ред. И. А. Курзиной [и др.].— .— Томск: Изд-во ТПУ
Т. 2 : Химия.— 2025.— С. 130-132
Main Author: Кольцова А. В.
Other Authors: Михневич Е. И. (727), Соломоненко А. Н. Анна Николаевна, Дорожко Е. В. Елена Владимировна
Summary:Заглавие с экрана
Currently, vaccine development requires significant time and financial costs, and their quality assessment requires the use of complex and expensive methods. Enzyme-linked immunosorbent assay (ELISA), while remaining one of the most common vaccine quality control methods, requires a long analysis time and often uses horseradish peroxidase (HRP) as an enzyme label. HRP production is characterized by high cost and low product yield, which stimulates the search for alternative enzyme labels. In this study, a new strategy for synthesizing a conjugate based on invertase and immunoglobulins of class G is proposed. Invertase, which catalyzes the hydrolysis of sucrose to form glucose, allows the use of a personal glucose meter to record the analytical signal. This significantly simplifies and accelerates the process of assessing the quality of immunobiological products, making it more accessible to laboratories with limited resources and for express tests. The aim of the work is to develop a conjugate based on invertase and antibodies in an immunoassay using a glucose meter. The developed method, based on the use of a personal glucose meter, will provide a convenient, fast and cost-effective way to control the quality of vaccines, and will also be potentially suitable for use in various conditions
Текстовый файл
Published: 2025
Subjects:
труды учёных ТПУ
электронный ресурс
invertase
enzyme immunoassay
glutaraldehyde
glucose meter
hepatitis A virus
Online Access:http://earchive.tpu.ru/handle/11683/132825
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=682389

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