Synthesis and biological evaluation of alkali metal salts of tryptanthrin-6-oxime; 53rd International Union of Pure & Applied Chemistry General Assembly (IUPAC 2025) and 50th World Chemistry Congress (50WCC)
| Источник: | 53rd International Union of Pure & Applied Chemistry General Assembly (IUPAC 2025) and 50th World Chemistry Congress (50WCC).— 2025.— P. 210 |
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| Главный автор: | |
| Другие авторы: | , |
| Примечания: | Title screen Indolo[2,1-b]quinazolin-6,12-dione oxime (tryptanthrin-6-oxime, Tryp-Ox) exhibit a variety of chemical properties and pharmacological activities. Owing to ion-chelating properties, oximes can be ligands in various complexes formed by metal ions. As the complex formation can affect biological activity of oximes, we decided to obtain a series of alkali metal salts (oximates) containing the Tryp-Ox scaffold (Figure 1) and study their solubility and cytotoxicity. Previously we synthesized lithium and sodium salts of Tryp-Ox and established their high affinity for JNK1-3 (Kd < 1 μM) and potent inhibition of LPS-induced nuclear NF-κB/AP-1 activation and IL-6 production in human monocytic cells [1]. The c-Jun N-terminal kinase (JNK) pathway is a dual-functional oncogenic signaling that exerts both anti- and pro-tumor activities [2,3]. In this research we focused on evaluation the antitumor activity of oximates Текстовый файл |
| Язык: | английский |
| Опубликовано: |
2025
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| Предметы: | |
| Online-ссылка: | https://iupac-2025.s3.ap-southeast-1.amazonaws.com/j3y8n5cpauaosv9ekold8novsqtj#page=210 |
| Формат: | Электронный ресурс Статья |
| Запись в KOHA: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=682288 |
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| 200 | 1 | |a Synthesis and biological evaluation of alkali metal salts of tryptanthrin-6-oxime |f Kovrizhina A. R., Khlebnikov A. I., Plotnikov E. V. | |
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| 330 | |a Indolo[2,1-b]quinazolin-6,12-dione oxime (tryptanthrin-6-oxime, Tryp-Ox) exhibit a variety of chemical properties and pharmacological activities. Owing to ion-chelating properties, oximes can be ligands in various complexes formed by metal ions. As the complex formation can affect biological activity of oximes, we decided to obtain a series of alkali metal salts (oximates) containing the Tryp-Ox scaffold (Figure 1) and study their solubility and cytotoxicity. Previously we synthesized lithium and sodium salts of Tryp-Ox and established their high affinity for JNK1-3 (Kd < 1 μM) and potent inhibition of LPS-induced nuclear NF-κB/AP-1 activation and IL-6 production in human monocytic cells [1]. The c-Jun N-terminal kinase (JNK) pathway is a dual-functional oncogenic signaling that exerts both anti- and pro-tumor activities [2,3]. In this research we focused on evaluation the antitumor activity of oximates | ||
| 336 | |a Текстовый файл | ||
| 463 | 1 | |t 53rd International Union of Pure & Applied Chemistry General Assembly (IUPAC 2025) and 50th World Chemistry Congress (50WCC) |o e-Abstract Book, Kuala Lumpur, Malaysia, 12-16 July 2025 and 14-19 July 2025 |c Bandar Bangi |n National University of Malaysia |d 2025 |v P. 210 |y 978-5-4437-1350-2 | |
| 610 | 1 | |a alkali salts | |
| 610 | 1 | |a tryptanthrin-6-oxime | |
| 610 | 1 | |a solubility | |
| 610 | 1 | |a cytotoxicity | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a электронный ресурс | |
| 700 | 1 | |a Kovrizhina |b A. R. |c biotechnology specialist |c Research Engineer of Tomsk Polytechnic University |f 1995- |g Anastasia Ruslanovna |9 22266 | |
| 701 | 1 | |a Khlebnikov |b A. I. |c Chemist |c Professor of Tomsk Polytechnic University |f 1963- |g Andrey Ivanovich |9 17500 | |
| 701 | 1 | |a Plotnikov |b E. V. |c chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences |f 1983- |g Evgeny Vladimirovich |9 16417 | |
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