Immunotoxicity Study of Cucurbit[n]urils (n = 6, 7, 8) and Modeling of Interaction with Some Monocyte Receptors by a Molecular Docking Method; Molecules; Vol. 30, iss. 10

Immunotoxicity Study of Cucurbit[n]urils (n = 6, 7, 8) and Modeling of Interaction with Some Monocyte Receptors by a Molecular Docking Method

Bibliografiske detaljer
Parent link:Molecules.— .— Basel: MDPI AG
Vol. 30, iss. 10.— 2025.— Article number 2249, 19 p.
Andre forfattere: Zhautikova S. B. Saule, Abdykhanova N. N. Nursipat, Fedorishin D. A. Dmitry, Shapovalova E. G. Elena Grigorjevna, Khlebnikov A. I. Andrey Ivanovich, Bakibaev A. A. Abdigali Abdimanapovich, Kurzina I. A. Irina Aleksandrovna, Kabieva S. K. Saule Kazzhanovna, Boranbay N., Zhumanazarova G. M. Gaziza
Summary:Title screen
In this study, cucurbit[n]urils (n = 6, 7, 8) were carefully evaluated for their cytotoxicity and immunotoxicity to human peripheral blood monocytes. The cytotoxicity was studied by evaluating the survival of monocytes, while the immunotoxicity level was assessed by analyzing the inflammatory mediators secreted by them using an enzyme-linked immunosorbent assay. It was found that cucurbit[n]urils (n = 6, 7, 8) in the used concentration (10−5 M) do not cause a negative effect on cell viability, which is maintained at a level above 50%. At the same time, cucurbit[n]urils (n = 6, 7, 8) do not cause pro-inflammatory activation of monocytic macrophages. The absence of stimulation of pro-inflammatory cytokine expression demonstrates the promising biocompatibility of the studied compounds, which is crucial for their successful clinical use. The obtained results of molecular modeling show the possibility of formation of CB[6], CB[7], and CB[8] associates with various Toll-like receptors, which also confirms good prospects for the development of new ways of medical application of cucurbit[n]urils
Текстовый файл
Sprog:engelsk
Udgivet: 2025
Fag:
cucurbit[6]uril
cucurbit[7]uril
cucurbit[8]uril
monocytes; cytotoxicity
immunotoxicity
Toll-like receptors
molecular docking
электронный ресурс
труды учёных ТПУ
Online adgang:https://doi.org/10.3390/molecules30102249
Format: Electronisk Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=682278

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