Immunotoxicity Study of Cucurbit[n]urils (n = 6, 7, 8) and Modeling of Interaction with Some Monocyte Receptors by a Molecular Docking Method; Molecules; Vol. 30, iss. 10
| Parent link: | Molecules.— .— Basel: MDPI AG Vol. 30, iss. 10.— 2025.— Article number 2249, 19 p. |
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| Drugi avtorji: | , , , , , , , , , |
| Izvleček: | Title screen In this study, cucurbit[n]urils (n = 6, 7, 8) were carefully evaluated for their cytotoxicity and immunotoxicity to human peripheral blood monocytes. The cytotoxicity was studied by evaluating the survival of monocytes, while the immunotoxicity level was assessed by analyzing the inflammatory mediators secreted by them using an enzyme-linked immunosorbent assay. It was found that cucurbit[n]urils (n = 6, 7, 8) in the used concentration (10−5 M) do not cause a negative effect on cell viability, which is maintained at a level above 50%. At the same time, cucurbit[n]urils (n = 6, 7, 8) do not cause pro-inflammatory activation of monocytic macrophages. The absence of stimulation of pro-inflammatory cytokine expression demonstrates the promising biocompatibility of the studied compounds, which is crucial for their successful clinical use. The obtained results of molecular modeling show the possibility of formation of CB[6], CB[7], and CB[8] associates with various Toll-like receptors, which also confirms good prospects for the development of new ways of medical application of cucurbit[n]urils Текстовый файл |
| Jezik: | angleščina |
| Izdano: |
2025
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| Teme: | |
| Online dostop: | https://doi.org/10.3390/molecules30102249 |
| Format: | xMaterials Elektronski Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=682278 |
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| 200 | 1 | |a Immunotoxicity Study of Cucurbit[n]urils (n = 6, 7, 8) and Modeling of Interaction with Some Monocyte Receptors by a Molecular Docking Method |f Saule B. Zhautikova, Nursipat N. Abdykhanova, Dmitry A. Fedorishin [et al.] | |
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| 300 | |a Title screen | ||
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| 330 | |a In this study, cucurbit[n]urils (n = 6, 7, 8) were carefully evaluated for their cytotoxicity and immunotoxicity to human peripheral blood monocytes. The cytotoxicity was studied by evaluating the survival of monocytes, while the immunotoxicity level was assessed by analyzing the inflammatory mediators secreted by them using an enzyme-linked immunosorbent assay. It was found that cucurbit[n]urils (n = 6, 7, 8) in the used concentration (10−5 M) do not cause a negative effect on cell viability, which is maintained at a level above 50%. At the same time, cucurbit[n]urils (n = 6, 7, 8) do not cause pro-inflammatory activation of monocytic macrophages. The absence of stimulation of pro-inflammatory cytokine expression demonstrates the promising biocompatibility of the studied compounds, which is crucial for their successful clinical use. The obtained results of molecular modeling show the possibility of formation of CB[6], CB[7], and CB[8] associates with various Toll-like receptors, which also confirms good prospects for the development of new ways of medical application of cucurbit[n]urils | ||
| 336 | |a Текстовый файл | ||
| 461 | 1 | |t Molecules |c Basel |n MDPI AG | |
| 463 | 1 | |t Vol. 30, iss. 10 |v Article number 2249, 19 p. |d 2025 | |
| 610 | 1 | |a cucurbit[6]uril | |
| 610 | 1 | |a cucurbit[7]uril | |
| 610 | 1 | |a cucurbit[8]uril | |
| 610 | 1 | |a monocytes; cytotoxicity | |
| 610 | 1 | |a immunotoxicity | |
| 610 | 1 | |a Toll-like receptors | |
| 610 | 1 | |a molecular docking | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Zhautikova |b S. B. |g Saule | |
| 701 | 1 | |a Abdykhanova |b N. N. |g Nursipat | |
| 701 | 1 | |a Fedorishin |b D. A. |g Dmitry | |
| 701 | 1 | |a Shapovalova |b E. G. |g Elena Grigorjevna | |
| 701 | 1 | |a Khlebnikov |b A. I. |c Chemist |c Professor of Tomsk Polytechnic University |f 1963- |g Andrey Ivanovich |9 17500 | |
| 701 | 1 | |a Bakibaev |b A. A. |c Russian chemist |c Professor of TPU, doctor of chemical sciences |f 1960- |g Abdigali Abdimanapovich |9 12886 | |
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