Regulation of Blood–Brain Barrier Permeability via JNK Signaling Pathway: Mechanisms and Potential Therapeutic Strategies for Ischemic Stroke, Alzheimer’s Disease and Brain Tumors; Molecules; Vol. 30, iss. 11

Regulation of Blood–Brain Barrier Permeability via JNK Signaling Pathway: Mechanisms and Potential Therapeutic Strategies for Ischemic Stroke, Alzheimer’s Disease and Brain Tumors; Molecules; Vol. 30, iss. 11

Bibliographic Details
Parent link:Molecules.— .— Basel: MDPI AG
Vol. 30, iss. 11.— 2025.— Article number 2353, 26 p.
Other Authors: Plotnikov M. B., Anishchenko A. M., Khlebnikov A. I. Andrey Ivanovich, Schepetkin I. A. Igor
Summary:Title screen
Disruption of the blood–brain barrier (BBB) accompanies many brain diseases, including stroke, neurodegenerative diseases, and brain tumors, leading to swelling, increased neuroinflammation, and neuronal death. In recent years, it has become clear that the c-Jun N-terminal kinase (JNK) signaling pathway is involved in disruption of the structural integrity of the BBB. Activation of the JNK signaling pathway has a negative effect on the functioning of the cellular elements of the neurovascular unit that form the BBB. The aim of this review is to assess the role of the JNK signaling pathway in the disruption of the structural integrity of the BBB in animal models of stroke (MCAO/R, middle cerebral artery occlusion with reperfusion), Alzheimer’s disease, and brain tumors and to analyze the effects of compounds of various natures that directly or indirectly affect the activity of the JNK signaling pathway. These compounds can reduce damage to the BBB and brain edema, reduce neuroinflammation and oxidative stress, reduce the expression of proapoptotic factors, and increase the expression of tight junction proteins. Certain compounds mitigate BBB dysfunction, being promising candidates for neuroprotective therapies. These agents exert their effects, in part, through inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway, a mechanism linked to reduced neuronal damage and improved BBB integrity
Текстовый файл
Language:English
Published: 2025
Subjects:
Alzheimer’s disease
blood–brain barrier
brain tumor
ischemia/reperfusion
c-Jun N-terminal kinase (JNK)
JNK pathway
JNK inhibitor
электронный ресурс
труды учёных ТПУ
Online Access:https://doi.org/10.3390/molecules30112353
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=682272

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