Luminescent Properties and Cytotoxic Activity of 2-phenylbenzoxazole Fluorosulfate Derivatives; International Journal of Molecular Sciences; Vol. 26, iss. 15
| Parent link: | International Journal of Molecular Sciences.— .— Basel: MDPI AG Vol. 26, iss. 15.— 2025.— Article number 7261, 19 p. |
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| Awduron Eraill: | , , , , , , , , |
| Crynodeb: | Title screen The synthesis of 2-phenylbenzoxazole fluorosulfate derivatives was carried out using the SuFEx reaction. To study the anticancer properties of the obtained compounds, the cell lines PC-3 (obtained from prostate adenocarcinoma), BT-474, and MCF-7 (both obtained from breast carcinoma) were used. The cytotoxicity on murine 3T3L1 embryonic was also investigated. Among the tested compounds, the ortho-substituted fluorosulfate derivative (BOSo) exhibited significant cytotoxicity against MCF-7 cells. The biological findings are consistent with molecular docking results, which revealed a structural similarity between BOSo and known inhibitors of hER and HER2 receptors—tamoxifen and SYR127063. Therefore, BOSo shows promise as a potential therapeutic agent with antiproliferative properties. The photoluminescent characteristics of the fluorosulfate derivatives were examined in the solid state, in acetonitrile solution and in PBS, with the highest quantum yields reaching up to 64% for the para-fluorosulfate derivative in acetonitrile. Overall, these compounds demonstrate considerable potential for the development of new multifunctional molecular tools that combine biological activity with fluorescent properties Текстовый файл |
| Iaith: | Saesneg |
| Cyhoeddwyd: |
2025
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| Pynciau: | |
| Mynediad Ar-lein: | https://doi.org/10.3390/ijms26157261 |
| Fformat: | Electronig Pennod Llyfr |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=681719 |
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| 200 | 1 | |a Luminescent Properties and Cytotoxic Activity of 2-phenylbenzoxazole Fluorosulfate Derivatives |f Nadezhda V. Danilenko, Mariia O. Lutsuk, Alexey A. Ryadun [et al.] | |
| 203 | |a Текст |b визуальный |c электронный | ||
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| 300 | |a Title screen | ||
| 320 | |a References: 47 tit | ||
| 330 | |a The synthesis of 2-phenylbenzoxazole fluorosulfate derivatives was carried out using the SuFEx reaction. To study the anticancer properties of the obtained compounds, the cell lines PC-3 (obtained from prostate adenocarcinoma), BT-474, and MCF-7 (both obtained from breast carcinoma) were used. The cytotoxicity on murine 3T3L1 embryonic was also investigated. Among the tested compounds, the ortho-substituted fluorosulfate derivative (BOSo) exhibited significant cytotoxicity against MCF-7 cells. The biological findings are consistent with molecular docking results, which revealed a structural similarity between BOSo and known inhibitors of hER and HER2 receptors—tamoxifen and SYR127063. Therefore, BOSo shows promise as a potential therapeutic agent with antiproliferative properties. The photoluminescent characteristics of the fluorosulfate derivatives were examined in the solid state, in acetonitrile solution and in PBS, with the highest quantum yields reaching up to 64% for the para-fluorosulfate derivative in acetonitrile. Overall, these compounds demonstrate considerable potential for the development of new multifunctional molecular tools that combine biological activity with fluorescent properties | ||
| 336 | |a Текстовый файл | ||
| 461 | 1 | |t International Journal of Molecular Sciences |c Basel |n MDPI AG | |
| 463 | 1 | |t Vol. 26, iss. 15 |v Article number 7261, 19 p. |d 2025 | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a benzoxazole | |
| 610 | 1 | |a SuFEx | |
| 610 | 1 | |a fluorescence | |
| 610 | 1 | |a antitumor activity | |
| 701 | 1 | |a Danilenko |b N. V. |c chemical engineer |c Research Engineer, Tomsk Polytechnic University |f 1992- |g Nadezhda Viktorovna |9 20416 | |
| 701 | 1 | |a Lutsuk |b M. O. |g Mariya Olegovna | |
| 701 | 1 | |a Ryadun |b A. A. |g Alexey Andreevich | |
| 701 | 1 | |a Pavlov |b D. I. |g Dmitry Igorevich | |
| 701 | 1 | |a Plotnikov |b E. V. |c chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences |f 1983- |g Evgeny Vladimirovich |9 16417 | |
| 701 | 1 | |a Eskova |b D. D. |g Darjya Dmitrievna |f 2003- |c biotechnologist |c laboratory assistant of Tomsk Polytechnic University |9 88808 | |
| 701 | 1 | |a Klimenko |b Yu. D. |g Yuliya Dmitrievna | |
| 701 | 1 | |a Potapov |b A. S. |g Andrey Sergeevich | |
| 701 | 1 | |a Khlebnikov |b A. I. |c Chemist |c Professor of Tomsk Polytechnic University |f 1963- |g Andrey Ivanovich |9 17500 | |
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